Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072901265> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2072901265 endingPage "944" @default.
- W2072901265 startingPage "935" @default.
- W2072901265 abstract "HIV-1 vpr encodes a 96-amino acid, nuclear protein whose function is not well understood. Unlike the other lentivirus regulatory proteins, Vpr is present in virions at relatively high copy number. In cells, Vpr is localized to the nucleus. Possible functions for vpr consistent with these findings include the nuclear import of preintegration complexes, transactivation of cellular genes, or induction of cellular differentiation. We show here, using both replication competent, macrophage-tropic virus and a sensitive, single-cycle luciferase HIV-1 reporter vector, that vpr is important for efficient viral replication in primary monocyte/macrophages, but appears to play no role in activated or resting T cell infection. The block to infection in monocytes was localized by PCR analysis of newly synthesized viral DNA and with the luciferase reporter vector to a stage in the viral life cycle after entry and reverse transcription, yet prior to, or at the time of, proviral transcription. In addition, infection of mononuclear phagocytes with virions that had been loaded with Vpr molecules in the producer cells by trans-complementation still showed a vpr-phenotype. These data suggest a role for vpr molecules produced in newly infected cells, in addition to its presumed function in the virion." @default.
- W2072901265 created "2016-06-24" @default.
- W2072901265 creator A5020311779 @default.
- W2072901265 creator A5024206468 @default.
- W2072901265 creator A5026884851 @default.
- W2072901265 creator A5036106449 @default.
- W2072901265 date "1995-02-01" @default.
- W2072901265 modified "2023-10-18" @default.
- W2072901265 title "Vpr Is Required for Efficient Replication of Human Immunodeficiency Virus Type-1 in Mononuclear Phagocytes" @default.
- W2072901265 doi "https://doi.org/10.1006/viro.1995.1016" @default.
- W2072901265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7531918" @default.
- W2072901265 hasPublicationYear "1995" @default.
- W2072901265 type Work @default.
- W2072901265 sameAs 2072901265 @default.
- W2072901265 citedByCount "1200" @default.
- W2072901265 countsByYear W20729012652012 @default.
- W2072901265 countsByYear W20729012652013 @default.
- W2072901265 countsByYear W20729012652014 @default.
- W2072901265 countsByYear W20729012652015 @default.
- W2072901265 countsByYear W20729012652016 @default.
- W2072901265 countsByYear W20729012652017 @default.
- W2072901265 countsByYear W20729012652018 @default.
- W2072901265 countsByYear W20729012652019 @default.
- W2072901265 countsByYear W20729012652020 @default.
- W2072901265 countsByYear W20729012652021 @default.
- W2072901265 countsByYear W20729012652022 @default.
- W2072901265 countsByYear W20729012652023 @default.
- W2072901265 crossrefType "journal-article" @default.
- W2072901265 hasAuthorship W2072901265A5020311779 @default.
- W2072901265 hasAuthorship W2072901265A5024206468 @default.
- W2072901265 hasAuthorship W2072901265A5026884851 @default.
- W2072901265 hasAuthorship W2072901265A5036106449 @default.
- W2072901265 hasBestOaLocation W20729012651 @default.
- W2072901265 hasConcept C104317684 @default.
- W2072901265 hasConcept C1292079 @default.
- W2072901265 hasConcept C138885662 @default.
- W2072901265 hasConcept C140704245 @default.
- W2072901265 hasConcept C150194340 @default.
- W2072901265 hasConcept C153911025 @default.
- W2072901265 hasConcept C159047783 @default.
- W2072901265 hasConcept C161733203 @default.
- W2072901265 hasConcept C179926584 @default.
- W2072901265 hasConcept C2522874641 @default.
- W2072901265 hasConcept C25897203 @default.
- W2072901265 hasConcept C2780114586 @default.
- W2072901265 hasConcept C2780723820 @default.
- W2072901265 hasConcept C41895202 @default.
- W2072901265 hasConcept C54009773 @default.
- W2072901265 hasConcept C54355233 @default.
- W2072901265 hasConcept C59157529 @default.
- W2072901265 hasConcept C86339819 @default.
- W2072901265 hasConcept C86803240 @default.
- W2072901265 hasConcept C95444343 @default.
- W2072901265 hasConceptScore W2072901265C104317684 @default.
- W2072901265 hasConceptScore W2072901265C1292079 @default.
- W2072901265 hasConceptScore W2072901265C138885662 @default.
- W2072901265 hasConceptScore W2072901265C140704245 @default.
- W2072901265 hasConceptScore W2072901265C150194340 @default.
- W2072901265 hasConceptScore W2072901265C153911025 @default.
- W2072901265 hasConceptScore W2072901265C159047783 @default.
- W2072901265 hasConceptScore W2072901265C161733203 @default.
- W2072901265 hasConceptScore W2072901265C179926584 @default.
- W2072901265 hasConceptScore W2072901265C2522874641 @default.
- W2072901265 hasConceptScore W2072901265C25897203 @default.
- W2072901265 hasConceptScore W2072901265C2780114586 @default.
- W2072901265 hasConceptScore W2072901265C2780723820 @default.
- W2072901265 hasConceptScore W2072901265C41895202 @default.
- W2072901265 hasConceptScore W2072901265C54009773 @default.
- W2072901265 hasConceptScore W2072901265C54355233 @default.
- W2072901265 hasConceptScore W2072901265C59157529 @default.
- W2072901265 hasConceptScore W2072901265C86339819 @default.
- W2072901265 hasConceptScore W2072901265C86803240 @default.
- W2072901265 hasConceptScore W2072901265C95444343 @default.
- W2072901265 hasIssue "2" @default.
- W2072901265 hasLocation W20729012651 @default.
- W2072901265 hasLocation W20729012652 @default.
- W2072901265 hasOpenAccess W2072901265 @default.
- W2072901265 hasPrimaryLocation W20729012651 @default.
- W2072901265 hasRelatedWork W1838492020 @default.
- W2072901265 hasRelatedWork W1973250744 @default.
- W2072901265 hasRelatedWork W1996287598 @default.
- W2072901265 hasRelatedWork W2059679525 @default.
- W2072901265 hasRelatedWork W2082926700 @default.
- W2072901265 hasRelatedWork W2084750392 @default.
- W2072901265 hasRelatedWork W2118124483 @default.
- W2072901265 hasRelatedWork W2153936596 @default.
- W2072901265 hasRelatedWork W2414706654 @default.
- W2072901265 hasRelatedWork W4365452711 @default.
- W2072901265 hasVolume "206" @default.
- W2072901265 isParatext "false" @default.
- W2072901265 isRetracted "false" @default.
- W2072901265 magId "2072901265" @default.
- W2072901265 workType "article" @default.