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• W2072902666 abstract "Dideoxy bicyclic pyrimidine nucleoside analogues (ddBCNAs) with d-chirality have previously been described by us to inhibit replication of human cytomegalovirus. We herein report for the first time that activity against vaccinia virus (VACV) was achieved using novel l-analogues. A structure–activity relationship was established: Antiviral activity versus VACV was highest with an ether side chain with an optimum of n-C9H18–O–n-C5H11. This gave an IC50 of 190 nM, a 60-fold enhancement over the FDA-approved antiviral cidofovir. Interestingly, l-ddBCNAs also inhibit wild type measles virus syncytia formation with a TCID50 of 7.5 μM for the lead compound. We propose that l-ddBCNAs represent significant innovative antiviral candidates versus measles and poxviruses, and we suggest a mechanism of action versus one or more cellular targets that are essential for viral replication." @default.
• W2072902666 created "2016-06-24" @default.
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• W2072902666 date "2013-01-29" @default.
• W2072902666 modified "2023-10-14" @default.
• W2072902666 title "Novel Antiviral Activity of <scp>l</scp>-Dideoxy Bicyclic Nucleoside Analogues versus Vaccinia and Measles Viruses in Vitro" @default.
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• W2072902666 doi "https://doi.org/10.1021/jm301778x" @default.
• W2072902666 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23320521" @default.
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