FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072904239> ?p ?o ?g. }

• W2072904239 abstract "Introduction: Local tumour invasion gives rise to recurrence after surgical resection, leading to the poor prognosis associated with malignant astrocytomas. Extracellular proteolytic enzymes including cysteine proteinases have been implicated in facilitating tumour cell invasion. The current study was designed to characterize the expression of the cysteine proteinase, cathepsin S and investigate its potential role in the invasive process.Materials and methods: Expression of cathepsin S was investigated in astrocytoma biopsies by immunohistochemistry and in astrocytoma cultures by immunocytochemistry and the reverse transcription polymerase chain reaction. Cathepsin S activity assays were also performed on in vitro and in vivo samples. An in vitro Matrigel invasion assay was used to evaluate the effect of selective cathepsin S inactivation, by the inhibitor LHVS, on glioblastoma cell invasion.Results: Cathepsin S immunostaining was restricted to tumour cells in vivo. Cathepsin S transcript, protein and activity were observed within astrocytoma cells in vitro. Extracellular cathepsin S activity was about five-fold higher in cultures from grade IV tumours than in lower grades. Inhibition of cathepsin S with 0.01 µm LHVS significantly inhibited in vitro invasion of the glioblastoma cell line U251 mg by 50% (P < 0.0001).Conclusions: It has been demonstrated for the first time that cathepsin S is expressed and secreted by astrocytoma cells and plays a role in astrocytoma invasion, and is therefore a potential therapeutic target." @default.
• W2072904239 created "2016-06-24" @default.
• W2072904239 creator A5039173179 @default.
• W2072904239 creator A5050632069 @default.
• W2072904239 creator A5065201951 @default.
• W2072904239 creator A5074198957 @default.
• W2072904239 creator A5090222932 @default.
• W2072904239 date "2002-03-01" @default.
• W2072904239 modified "2023-09-28" @default.
• W2072904239 title "The role of the cysteine proteinase cathepsin S in astrocytoma invasion" @default.
• W2072904239 doi "https://doi.org/10.1046/j.1365-2990.2002.39286_23.x" @default.
• W2072904239 hasPublicationYear "2002" @default.
• W2072904239 type Work @default.
• W2072904239 sameAs 2072904239 @default.
• W2072904239 citedByCount "0" @default.
• W2072904239 crossrefType "journal-article" @default.
• W2072904239 hasAuthorship W2072904239A5039173179 @default.
• W2072904239 hasAuthorship W2072904239A5050632069 @default.
• W2072904239 hasAuthorship W2072904239A5065201951 @default.
• W2072904239 hasAuthorship W2072904239A5074198957 @default.
• W2072904239 hasAuthorship W2072904239A5090222932 @default.
• W2072904239 hasBestOaLocation W20729042392 @default.
• W2072904239 hasConcept C104317684 @default.
• W2072904239 hasConcept C11957725 @default.
• W2072904239 hasConcept C142724271 @default.
• W2072904239 hasConcept C150903083 @default.
• W2072904239 hasConcept C151701858 @default.
• W2072904239 hasConcept C153911025 @default.
• W2072904239 hasConcept C167844969 @default.
• W2072904239 hasConcept C181199279 @default.
• W2072904239 hasConcept C202751555 @default.
• W2072904239 hasConcept C203014093 @default.
• W2072904239 hasConcept C204232928 @default.
• W2072904239 hasConcept C207001950 @default.
• W2072904239 hasConcept C2776415932 @default.
• W2072904239 hasConcept C2778227246 @default.
• W2072904239 hasConcept C2778608917 @default.
• W2072904239 hasConcept C2778880634 @default.
• W2072904239 hasConcept C2780034444 @default.
• W2072904239 hasConcept C28021979 @default.
• W2072904239 hasConcept C28406088 @default.
• W2072904239 hasConcept C4224716 @default.
• W2072904239 hasConcept C502942594 @default.
• W2072904239 hasConcept C54355233 @default.
• W2072904239 hasConcept C55493867 @default.
• W2072904239 hasConcept C71924100 @default.
• W2072904239 hasConcept C81885089 @default.
• W2072904239 hasConcept C86803240 @default.
• W2072904239 hasConceptScore W2072904239C104317684 @default.
• W2072904239 hasConceptScore W2072904239C11957725 @default.
• W2072904239 hasConceptScore W2072904239C142724271 @default.
• W2072904239 hasConceptScore W2072904239C150903083 @default.
• W2072904239 hasConceptScore W2072904239C151701858 @default.
• W2072904239 hasConceptScore W2072904239C153911025 @default.
• W2072904239 hasConceptScore W2072904239C167844969 @default.
• W2072904239 hasConceptScore W2072904239C181199279 @default.
• W2072904239 hasConceptScore W2072904239C202751555 @default.
• W2072904239 hasConceptScore W2072904239C203014093 @default.
• W2072904239 hasConceptScore W2072904239C204232928 @default.
• W2072904239 hasConceptScore W2072904239C207001950 @default.
• W2072904239 hasConceptScore W2072904239C2776415932 @default.
• W2072904239 hasConceptScore W2072904239C2778227246 @default.
• W2072904239 hasConceptScore W2072904239C2778608917 @default.
• W2072904239 hasConceptScore W2072904239C2778880634 @default.
• W2072904239 hasConceptScore W2072904239C2780034444 @default.
• W2072904239 hasConceptScore W2072904239C28021979 @default.
• W2072904239 hasConceptScore W2072904239C28406088 @default.
• W2072904239 hasConceptScore W2072904239C4224716 @default.
• W2072904239 hasConceptScore W2072904239C502942594 @default.
• W2072904239 hasConceptScore W2072904239C54355233 @default.
• W2072904239 hasConceptScore W2072904239C55493867 @default.
• W2072904239 hasConceptScore W2072904239C71924100 @default.
• W2072904239 hasConceptScore W2072904239C81885089 @default.
• W2072904239 hasConceptScore W2072904239C86803240 @default.
• W2072904239 hasLocation W20729042391 @default.
• W2072904239 hasLocation W20729042392 @default.
• W2072904239 hasOpenAccess W2072904239 @default.
• W2072904239 hasPrimaryLocation W20729042391 @default.
• W2072904239 hasRelatedWork W1598023718 @default.
• W2072904239 hasRelatedWork W1985506024 @default.
• W2072904239 hasRelatedWork W1999808993 @default.
• W2072904239 hasRelatedWork W2007519641 @default.
• W2072904239 hasRelatedWork W2016394200 @default.
• W2072904239 hasRelatedWork W2026345871 @default.
• W2072904239 hasRelatedWork W2052218939 @default.
• W2072904239 hasRelatedWork W2066050396 @default.
• W2072904239 hasRelatedWork W2085367227 @default.
• W2072904239 hasRelatedWork W2086710035 @default.
• W2072904239 hasRelatedWork W2087451489 @default.
• W2072904239 hasRelatedWork W2090751795 @default.
• W2072904239 hasRelatedWork W2131669932 @default.
• W2072904239 hasRelatedWork W2147259600 @default.
• W2072904239 hasRelatedWork W2148429670 @default.
• W2072904239 hasRelatedWork W2168740359 @default.
• W2072904239 hasRelatedWork W2369833714 @default.
• W2072904239 hasRelatedWork W2413391000 @default.
• W2072904239 hasRelatedWork W2414025369 @default.
• W2072904239 hasRelatedWork W94842645 @default.
• W2072904239 isParatext "false" @default.
• W2072904239 isRetracted "false" @default.

• next