Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072910036> ?p ?o ?g. }
- W2072910036 endingPage "5432" @default.
- W2072910036 startingPage "5425" @default.
- W2072910036 abstract "ABSTRACT Mammalian chromosomes terminate with a 3′ tail which consists of reiterations of the G-rich repeat, d(TTAGGG). The telomeric tail is the primer for replication by telomerase, and it may also invade telomeric duplex DNA to form terminal lariat structures, or T loops. Here we show that the ubiquitous and highly conserved mammalian protein hnRNP D interacts specifically with the G-rich strand of the telomeric repeat. A single gene encodes multiple isoforms of hnRNP D. All isoforms bind comparably to the G-rich strand, and certain isoforms can also bind tightly and specifically to the C-rich telomeric strand. G-rich telomeric sequences readily form structures stabilized by G-G pairing, which can interfere with telomere replication by telomerase. We show that hnRNP D binding to the G-rich strand destabilizes intrastrand G-G pairing and that hnRNP D interacts specifically with telomerase in human cell extracts. This biochemical analysis suggest that hnRNP D could function in vivo to destabilize structures formed by telomeric G-rich tails and facilitate their extension by telomerase." @default.
- W2072910036 created "2016-06-24" @default.
- W2072910036 creator A5006638225 @default.
- W2072910036 creator A5088715864 @default.
- W2072910036 date "2000-08-01" @default.
- W2072910036 modified "2023-10-16" @default.
- W2072910036 title "In Vitro Properties of the Conserved Mammalian Protein hnRNP D Suggest a Role in Telomere Maintenance" @default.
- W2072910036 cites W1533359580 @default.
- W2072910036 cites W1967554461 @default.
- W2072910036 cites W1970801073 @default.
- W2072910036 cites W1978002329 @default.
- W2072910036 cites W1979164620 @default.
- W2072910036 cites W1983823417 @default.
- W2072910036 cites W1987765621 @default.
- W2072910036 cites W1988669405 @default.
- W2072910036 cites W1993152080 @default.
- W2072910036 cites W1998405157 @default.
- W2072910036 cites W2001828972 @default.
- W2072910036 cites W2006547663 @default.
- W2072910036 cites W2013855617 @default.
- W2072910036 cites W2018635260 @default.
- W2072910036 cites W2019705337 @default.
- W2072910036 cites W2020133311 @default.
- W2072910036 cites W2028110618 @default.
- W2072910036 cites W2028800419 @default.
- W2072910036 cites W2032407757 @default.
- W2072910036 cites W2040204581 @default.
- W2072910036 cites W2040847130 @default.
- W2072910036 cites W2046892466 @default.
- W2072910036 cites W2050674095 @default.
- W2072910036 cites W2052968074 @default.
- W2072910036 cites W2056824225 @default.
- W2072910036 cites W2060017837 @default.
- W2072910036 cites W2061810442 @default.
- W2072910036 cites W2067081166 @default.
- W2072910036 cites W2072744580 @default.
- W2072910036 cites W2073722866 @default.
- W2072910036 cites W2076849957 @default.
- W2072910036 cites W2080489609 @default.
- W2072910036 cites W2081327669 @default.
- W2072910036 cites W2082127202 @default.
- W2072910036 cites W2083340704 @default.
- W2072910036 cites W2089609651 @default.
- W2072910036 cites W2090009109 @default.
- W2072910036 cites W2091138118 @default.
- W2072910036 cites W2091876286 @default.
- W2072910036 cites W2096259566 @default.
- W2072910036 cites W2101679570 @default.
- W2072910036 cites W2106111891 @default.
- W2072910036 cites W2111723163 @default.
- W2072910036 cites W2122658576 @default.
- W2072910036 cites W2127440297 @default.
- W2072910036 cites W2130118126 @default.
- W2072910036 cites W2132714970 @default.
- W2072910036 cites W2133038385 @default.
- W2072910036 cites W2136420353 @default.
- W2072910036 cites W2139793739 @default.
- W2072910036 cites W2141344821 @default.
- W2072910036 cites W2143022342 @default.
- W2072910036 cites W2143859021 @default.
- W2072910036 cites W2145554588 @default.
- W2072910036 cites W214734757 @default.
- W2072910036 cites W2150449890 @default.
- W2072910036 cites W2163805309 @default.
- W2072910036 cites W2164134985 @default.
- W2072910036 cites W2167635085 @default.
- W2072910036 cites W2168336539 @default.
- W2072910036 cites W4240115127 @default.
- W2072910036 doi "https://doi.org/10.1128/mcb.20.15.5425-5432.2000" @default.
- W2072910036 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/85994" @default.
- W2072910036 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10891483" @default.
- W2072910036 hasPublicationYear "2000" @default.
- W2072910036 type Work @default.
- W2072910036 sameAs 2072910036 @default.
- W2072910036 citedByCount "87" @default.
- W2072910036 countsByYear W20729100362012 @default.
- W2072910036 countsByYear W20729100362013 @default.
- W2072910036 countsByYear W20729100362014 @default.
- W2072910036 countsByYear W20729100362016 @default.
- W2072910036 countsByYear W20729100362019 @default.
- W2072910036 countsByYear W20729100362020 @default.
- W2072910036 countsByYear W20729100362021 @default.
- W2072910036 countsByYear W20729100362022 @default.
- W2072910036 countsByYear W20729100362023 @default.
- W2072910036 crossrefType "journal-article" @default.
- W2072910036 hasAuthorship W2072910036A5006638225 @default.
- W2072910036 hasAuthorship W2072910036A5088715864 @default.
- W2072910036 hasBestOaLocation W20729100361 @default.
- W2072910036 hasConcept C104317684 @default.
- W2072910036 hasConcept C177336024 @default.
- W2072910036 hasConcept C199216141 @default.
- W2072910036 hasConcept C202265312 @default.
- W2072910036 hasConcept C202751555 @default.
- W2072910036 hasConcept C3017666073 @default.
- W2072910036 hasConcept C54355233 @default.
- W2072910036 hasConcept C552990157 @default.
- W2072910036 hasConcept C86339819 @default.
- W2072910036 hasConcept C86803240 @default.