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• W2072910092 abstract "Regulatory T cells (Tregs) are thought to play a major role in pregnancy by inhibiting the maternal immune system and preventing fetal rejection. In decidual tissues, NK cells (dNK) reside in close contact with particular myelomonocytic CD14 + (dCD14 + ) cells. Here we show that the interaction between dNK and dCD14 + cells results in induction of Tregs. The interaction is mediated by soluble factors as shown by transwell experiments, and the prominent role of IFN-γ is revealed by the effect of a neutralizing monoclonal antibody. Following interaction with dNK cells, dCD14 + cells express indoleamine 2,3-dioxygenase (IDO), which, in turn, induces Tregs. Notably, unlike peripheral blood NK (pNK) cells, dNK cells are resistant to inhibition by the IDO metabolite L -kynurenine. “Conditioned” dCD14 + cells also may induce Tregs through transforming growth factor-β (TGF-β) production or CTLA-4–mediated interactions, as indicated by the effect of specific neutralizing Abs. Remarkably, only the interaction between dNK and dCD14 + cells results in Treg induction, whereas other coculture combinations involving either NK or CD14 + cells isolated from peripheral blood are ineffective. Our study provides interesting clues to understanding how the crosstalk between decidual NK and CD14 + cells may initiate a process that leads to Treg induction and immunosuppression. Along this line, it is conceivable that an impaired function of these cells may result in pregnancy failure." @default.
• W2072910092 created "2016-06-24" @default.
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• W2072910092 date "2010-06-14" @default.
• W2072910092 modified "2023-10-11" @default.
• W2072910092 title "Crosstalk between decidual NK and CD14 ⁺ myelomonocytic cells results in induction of Tregs and immunosuppression" @default.
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• W2072910092 doi "https://doi.org/10.1073/pnas.1001749107" @default.
• W2072910092 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2900704" @default.
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