Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072912136> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2072912136 endingPage "37" @default.
- W2072912136 startingPage "31" @default.
- W2072912136 abstract "Three patients with graft-versus-host-like enterocolonopathy are reported. Their history was remarkable for thymoma and other autoimmune manifestations such as thrombocytopenia, red cell aplasia, interface dermatitis, Sjogren sialadenits, vanishing bile ducts and rheumatoid arthritis. In all patients, microsatellite analysis showed the autologous nature of the lymphocytes in the affected organs ruling out GVHD. In search for mechanisms that could mediate loss of tolerance to self-antigens we found in a panel of thymomas, including those of the three patients, a complete lack of autoimmune regulator (AIRE) and minimal expression of the transcription factor FOXP3 in the intra-tumoral T cells. AIRE is a recently discovered transcription factor which plays a key role in the maintenance of central tolerance and is mutated in the autosomal recessive autoimmune polyendocrinopathy syndrome APS-1. Our observations indicate that thymoma-related autoimmunity can potentially be elicited by an incomplete deletion of 'self'-specific T cells in concert with an insufficient formation of natural Tregs." @default.
- W2072912136 created "2016-06-24" @default.
- W2072912136 creator A5028161098 @default.
- W2072912136 creator A5032410098 @default.
- W2072912136 creator A5035916087 @default.
- W2072912136 creator A5036565670 @default.
- W2072912136 creator A5051256009 @default.
- W2072912136 creator A5057667502 @default.
- W2072912136 creator A5068068698 @default.
- W2072912136 creator A5071116527 @default.
- W2072912136 creator A5082816887 @default.
- W2072912136 date "2007-11-01" @default.
- W2072912136 modified "2023-10-17" @default.
- W2072912136 title "Graft-versus-host-like disease complicating thymoma: Lack of AIRE expression as a cause of non-hereditary autoimmunity?" @default.
- W2072912136 cites W1486722793 @default.
- W2072912136 cites W1499151513 @default.
- W2072912136 cites W1555988808 @default.
- W2072912136 cites W1998814322 @default.
- W2072912136 cites W2004282938 @default.
- W2072912136 cites W2018703348 @default.
- W2072912136 cites W2028222510 @default.
- W2072912136 cites W2050514979 @default.
- W2072912136 cites W2068544133 @default.
- W2072912136 cites W2083737302 @default.
- W2072912136 cites W2136757504 @default.
- W2072912136 cites W2138319166 @default.
- W2072912136 cites W2165214298 @default.
- W2072912136 cites W2168628806 @default.
- W2072912136 doi "https://doi.org/10.1016/j.imlet.2007.08.010" @default.
- W2072912136 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17928069" @default.
- W2072912136 hasPublicationYear "2007" @default.
- W2072912136 type Work @default.
- W2072912136 sameAs 2072912136 @default.
- W2072912136 citedByCount "36" @default.
- W2072912136 countsByYear W20729121362012 @default.
- W2072912136 countsByYear W20729121362014 @default.
- W2072912136 countsByYear W20729121362015 @default.
- W2072912136 countsByYear W20729121362016 @default.
- W2072912136 countsByYear W20729121362017 @default.
- W2072912136 countsByYear W20729121362018 @default.
- W2072912136 countsByYear W20729121362019 @default.
- W2072912136 countsByYear W20729121362020 @default.
- W2072912136 countsByYear W20729121362021 @default.
- W2072912136 countsByYear W20729121362022 @default.
- W2072912136 crossrefType "journal-article" @default.
- W2072912136 hasAuthorship W2072912136A5028161098 @default.
- W2072912136 hasAuthorship W2072912136A5032410098 @default.
- W2072912136 hasAuthorship W2072912136A5035916087 @default.
- W2072912136 hasAuthorship W2072912136A5036565670 @default.
- W2072912136 hasAuthorship W2072912136A5051256009 @default.
- W2072912136 hasAuthorship W2072912136A5057667502 @default.
- W2072912136 hasAuthorship W2072912136A5068068698 @default.
- W2072912136 hasAuthorship W2072912136A5071116527 @default.
- W2072912136 hasAuthorship W2072912136A5082816887 @default.
- W2072912136 hasConcept C159654299 @default.
- W2072912136 hasConcept C203014093 @default.
- W2072912136 hasConcept C2776566471 @default.
- W2072912136 hasConcept C2777422296 @default.
- W2072912136 hasConcept C2777575956 @default.
- W2072912136 hasConcept C2779075594 @default.
- W2072912136 hasConcept C2779159893 @default.
- W2072912136 hasConcept C2779727006 @default.
- W2072912136 hasConcept C2780007613 @default.
- W2072912136 hasConcept C2780130043 @default.
- W2072912136 hasConcept C71924100 @default.
- W2072912136 hasConcept C8891405 @default.
- W2072912136 hasConceptScore W2072912136C159654299 @default.
- W2072912136 hasConceptScore W2072912136C203014093 @default.
- W2072912136 hasConceptScore W2072912136C2776566471 @default.
- W2072912136 hasConceptScore W2072912136C2777422296 @default.
- W2072912136 hasConceptScore W2072912136C2777575956 @default.
- W2072912136 hasConceptScore W2072912136C2779075594 @default.
- W2072912136 hasConceptScore W2072912136C2779159893 @default.
- W2072912136 hasConceptScore W2072912136C2779727006 @default.
- W2072912136 hasConceptScore W2072912136C2780007613 @default.
- W2072912136 hasConceptScore W2072912136C2780130043 @default.
- W2072912136 hasConceptScore W2072912136C71924100 @default.
- W2072912136 hasConceptScore W2072912136C8891405 @default.
- W2072912136 hasIssue "1" @default.
- W2072912136 hasLocation W20729121361 @default.
- W2072912136 hasLocation W20729121362 @default.
- W2072912136 hasOpenAccess W2072912136 @default.
- W2072912136 hasPrimaryLocation W20729121361 @default.
- W2072912136 hasRelatedWork W1971307936 @default.
- W2072912136 hasRelatedWork W1978709190 @default.
- W2072912136 hasRelatedWork W2029384431 @default.
- W2072912136 hasRelatedWork W2055877239 @default.
- W2072912136 hasRelatedWork W2072912136 @default.
- W2072912136 hasRelatedWork W2096287500 @default.
- W2072912136 hasRelatedWork W2119100076 @default.
- W2072912136 hasRelatedWork W2129546463 @default.
- W2072912136 hasRelatedWork W2224247558 @default.
- W2072912136 hasRelatedWork W2918427612 @default.
- W2072912136 hasVolume "114" @default.
- W2072912136 isParatext "false" @default.
- W2072912136 isRetracted "false" @default.
- W2072912136 magId "2072912136" @default.
- W2072912136 workType "article" @default.