Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072914820> ?p ?o ?g. }
- W2072914820 endingPage "111" @default.
- W2072914820 startingPage "104" @default.
- W2072914820 abstract "The responsiveness of CYP1A (gene transcription and EROD enzyme activity) in the cell line Poeciliopsis lucida hepatoma (PLHC-1) upon exposure to extracts of contaminated soil samples was investigated and compared to levels of PCDD/PCDFs and PCBs including non-ortho obtained by GC/MS analysis. Soil samples A and B were collected in sites A and B. Two fractions, not purified (np) and purified (p), were obtained from each sample and analyzed for PCDD/PCDF and PCB content by GC/MS; in parallel they were tested for 24 h with PLHC-1. CYP1A response was investigated at gene (RT-qPCR) level and as 7-ethoxyresorufin-O-deethylase (EROD) enzyme activity. Chem-TEQs and Bio-TEQs were then calculated. ∑TEQ calculated for PCDD/Fs and PCBs was 0.081 pg/g and 20.32 pg/g for samples A and B, respectively. PLHC-1 showed less up-regulation of cyp1a gene on exposure to the two purified fractions (Ap 2.1-fold and Bp 1.8-fold) than to non-purified fractions (up to 15-fold for Anp and 13-fold for Bnp). EROD was also induced 2.38- and 9.44-fold in the two purified fractions (Ap and Bp) compared to model inducer 2,3,7,8-TCDD, and up to 16.03-fold for non-purified Anp and 33.79-fold for Bnp. The combination of CYP1A response, obtained in a PLHC-1 cell-based bioassay, with contaminant residue analysis provided a better description of the presence and toxicity of dioxin-like compounds in an environmental matrix." @default.
- W2072914820 created "2016-06-24" @default.
- W2072914820 creator A5002755713 @default.
- W2072914820 creator A5006329589 @default.
- W2072914820 creator A5025311850 @default.
- W2072914820 creator A5049645926 @default.
- W2072914820 creator A5053844536 @default.
- W2072914820 date "2013-08-01" @default.
- W2072914820 modified "2023-09-24" @default.
- W2072914820 title "Occurrence of PCDD/PCDFs and PCBs in soil and comparison with CYP1A response in PLHC-1 cell line" @default.
- W2072914820 cites W1840477957 @default.
- W2072914820 cites W1964066906 @default.
- W2072914820 cites W1967916567 @default.
- W2072914820 cites W1971892168 @default.
- W2072914820 cites W1984279963 @default.
- W2072914820 cites W1984481910 @default.
- W2072914820 cites W1984625435 @default.
- W2072914820 cites W1985706589 @default.
- W2072914820 cites W1991350445 @default.
- W2072914820 cites W1994128812 @default.
- W2072914820 cites W1995057998 @default.
- W2072914820 cites W1997614456 @default.
- W2072914820 cites W1998400348 @default.
- W2072914820 cites W2003274347 @default.
- W2072914820 cites W2005869512 @default.
- W2072914820 cites W2007066599 @default.
- W2072914820 cites W2008960508 @default.
- W2072914820 cites W2017613779 @default.
- W2072914820 cites W2030821079 @default.
- W2072914820 cites W2036982876 @default.
- W2072914820 cites W2037844852 @default.
- W2072914820 cites W2045371772 @default.
- W2072914820 cites W2049109740 @default.
- W2072914820 cites W2060162775 @default.
- W2072914820 cites W2061071783 @default.
- W2072914820 cites W2065735323 @default.
- W2072914820 cites W2065863261 @default.
- W2072914820 cites W2067242360 @default.
- W2072914820 cites W2067299837 @default.
- W2072914820 cites W2070383978 @default.
- W2072914820 cites W2072120823 @default.
- W2072914820 cites W2072435610 @default.
- W2072914820 cites W2073290120 @default.
- W2072914820 cites W2073512911 @default.
- W2072914820 cites W2082198315 @default.
- W2072914820 cites W2093399973 @default.
- W2072914820 cites W2093932231 @default.
- W2072914820 cites W2094551173 @default.
- W2072914820 cites W2108244474 @default.
- W2072914820 cites W2113750680 @default.
- W2072914820 cites W2122887522 @default.
- W2072914820 cites W2142495103 @default.
- W2072914820 cites W2164272361 @default.
- W2072914820 doi "https://doi.org/10.1016/j.ecoenv.2013.05.005" @default.
- W2072914820 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23731866" @default.
- W2072914820 hasPublicationYear "2013" @default.
- W2072914820 type Work @default.
- W2072914820 sameAs 2072914820 @default.
- W2072914820 citedByCount "3" @default.
- W2072914820 countsByYear W20729148202015 @default.
- W2072914820 countsByYear W20729148202016 @default.
- W2072914820 crossrefType "journal-article" @default.
- W2072914820 hasAuthorship W2072914820A5002755713 @default.
- W2072914820 hasAuthorship W2072914820A5006329589 @default.
- W2072914820 hasAuthorship W2072914820A5025311850 @default.
- W2072914820 hasAuthorship W2072914820A5049645926 @default.
- W2072914820 hasAuthorship W2072914820A5053844536 @default.
- W2072914820 hasConcept C104317684 @default.
- W2072914820 hasConcept C104488531 @default.
- W2072914820 hasConcept C107872376 @default.
- W2072914820 hasConcept C178790620 @default.
- W2072914820 hasConcept C181199279 @default.
- W2072914820 hasConcept C185592680 @default.
- W2072914820 hasConcept C18903297 @default.
- W2072914820 hasConcept C2225953 @default.
- W2072914820 hasConcept C2776044436 @default.
- W2072914820 hasConcept C2778209978 @default.
- W2072914820 hasConcept C2779732650 @default.
- W2072914820 hasConcept C2781338088 @default.
- W2072914820 hasConcept C43617362 @default.
- W2072914820 hasConcept C55493867 @default.
- W2072914820 hasConcept C82685317 @default.
- W2072914820 hasConcept C86803240 @default.
- W2072914820 hasConceptScore W2072914820C104317684 @default.
- W2072914820 hasConceptScore W2072914820C104488531 @default.
- W2072914820 hasConceptScore W2072914820C107872376 @default.
- W2072914820 hasConceptScore W2072914820C178790620 @default.
- W2072914820 hasConceptScore W2072914820C181199279 @default.
- W2072914820 hasConceptScore W2072914820C185592680 @default.
- W2072914820 hasConceptScore W2072914820C18903297 @default.
- W2072914820 hasConceptScore W2072914820C2225953 @default.
- W2072914820 hasConceptScore W2072914820C2776044436 @default.
- W2072914820 hasConceptScore W2072914820C2778209978 @default.
- W2072914820 hasConceptScore W2072914820C2779732650 @default.
- W2072914820 hasConceptScore W2072914820C2781338088 @default.
- W2072914820 hasConceptScore W2072914820C43617362 @default.
- W2072914820 hasConceptScore W2072914820C55493867 @default.
- W2072914820 hasConceptScore W2072914820C82685317 @default.