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• W2072918492 abstract "Glaucoma is an age-related optic neuropathy involving sensitivity to ocular pressure. The disease is now seen increasingly as one of the central nervous system, as powerful new approaches highlight an increasing number of similarities with other age-related neurodegenerations such as Alzheimer's and Parkinson's. While the etiologies of these diseases are diverse, they involve many important common elements including compartmentalized programs of degeneration targeting axons, dendrites and finally cell bodies. Most age-related degenerations display early functional deficits that precede actual loss of neuronal substrate. These are linked to several specific neurochemical cascades that can be linked back to dysregulation of Ca2+-dependent processes. We are now in the midst of identifying similar cascades in glaucoma. Here we review recent evidence on the pathological progression of neurodegeneration in glaucoma and some of the Ca2+-dependent mechanisms that could underlie these changes. These mechanisms present clear implications for efforts to develop interventions targeting neuronal loss directly and make glaucoma an attractive model for both interrogating and informing other neurodegenerative diseases." @default.
• W2072918492 created "2016-06-24" @default.
• W2072918492 creator A5065709927 @default.
• W2072918492 creator A5076526686 @default.
• W2072918492 date "2011-03-01" @default.
• W2072918492 modified "2023-10-01" @default.
• W2072918492 title "Neurodegeneration in glaucoma: progression and calcium-dependent intracellular mechanisms" @default.
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