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- W2072920356 abstract "Integrase-binding domain (IBD) is a critical region on the lens epithelium-derived growth factor (LEDGF/p75) protein that specifically interacts with human immunodeficiency virus type 1 integrase (HIV-1 IN). In this study, we expressed and purified the IBD, and utilized in endonucleolytic assay and strand transfer assay to investigate whether IBD improve enzymatic activities of HIV-1 IN. Our results showed that IBD along with HIV-1 IN increased the strand transfer activity but not the endonucleolytic activity. Furthermore, our results showed that IBD induced efficient integration of the donor DNA into the target DNA to create half-site integration and full-site integration using plasmid as target DNA. Therefore, it is suggested that LEDGF-IBD itself might be able to increase viral infectivity by enhancing the strand transfer activities of HIV-1 IN and accelerating integration of viral cDNA into cellular chromosomal DNA." @default.
- W2072920356 created "2016-06-24" @default.
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- W2072920356 date "2015-02-10" @default.
- W2072920356 modified "2023-09-24" @default.
- W2072920356 title "Biochemical functions of integrase-binding domain of lens epithelium-derived growth factor" @default.
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- W2072920356 doi "https://doi.org/10.1080/19768354.2015.1008040" @default.
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