FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072925527> ?p ?o ?g. }

• W2072925527 endingPage "191" @default.
• W2072925527 startingPage "182" @default.
• W2072925527 abstract "The aim of this study was to investigate the role of genes and environment in susceptibility to breast cancer and to give an estimate of heritability in the propensity to develop the disease. To do this we applied an interdisciplinary approach, merging models developed in the field of demography and survival analysis - so-called frailty models - and models coming from quantitative genetics and epidemiology, namely genetic models. In our study, the inferential problem was solved in a Bayesian framework and the numerical work was carried out using MCMC methods. We used the special information coming from twin data, particularly breast cancer data, from the Swedish Twin Register. The application of a correlated log-normal frailty model leads to a very large estimate of the population heterogeneity (sigma = 6.7), and relatively small correlations between co-twins' frailties - around 0.3 for monozygotic and 0.1 for dizygotic twins. Comparing three different genetic models (an ACE, an AE and an ADE model), we furthermore concluded that genetic effects would explain globally almost 30% of the total variability of propensity to breast cancer. Environmental effects would be predominant in determining breast cancer susceptibility and these effects would be primarily individual-specific, that is, non-shared effects. Finally, a model which includes dominance genetic effects (ADE model) is preferred for genetic and statistical reasons." @default.
• W2072925527 created "2016-06-24" @default.
• W2072925527 creator A5014885809 @default.
• W2072925527 creator A5046450925 @default.
• W2072925527 creator A5053170977 @default.
• W2072925527 date "2004-04-01" @default.
• W2072925527 modified "2023-10-03" @default.
• W2072925527 title "The Heritability of Breast Cancer: A Bayesian Correlated Frailty Model Applied to Swedish Twins Data" @default.
• W2072925527 cites W1559784040 @default.
• W2072925527 cites W1566899673 @default.
• W2072925527 cites W1587982576 @default.
• W2072925527 cites W1912820264 @default.
• W2072925527 cites W1995618284 @default.
• W2072925527 cites W2013885224 @default.
• W2072925527 cites W2022592378 @default.
• W2072925527 cites W2027978397 @default.
• W2072925527 cites W2029046090 @default.
• W2072925527 cites W2044269646 @default.
• W2072925527 cites W2054957279 @default.
• W2072925527 cites W2056124784 @default.
• W2072925527 cites W2056760934 @default.
• W2072925527 cites W2062637647 @default.
• W2072925527 cites W2073358091 @default.
• W2072925527 cites W2084491175 @default.
• W2072925527 cites W2090081972 @default.
• W2072925527 cites W2113854409 @default.
• W2072925527 cites W2130065181 @default.
• W2072925527 cites W2157367015 @default.
• W2072925527 cites W2162948974 @default.
• W2072925527 cites W2323540307 @default.
• W2072925527 cites W4230655520 @default.
• W2072925527 cites W4241852510 @default.
• W2072925527 cites W4246464108 @default.
• W2072925527 cites W4249731213 @default.
• W2072925527 cites W4250065804 @default.
• W2072925527 cites W4253549618 @default.
• W2072925527 doi "https://doi.org/10.1375/twin.7.2.182" @default.
• W2072925527 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15169603" @default.
• W2072925527 hasPublicationYear "2004" @default.
• W2072925527 type Work @default.
• W2072925527 sameAs 2072925527 @default.
• W2072925527 citedByCount "20" @default.
• W2072925527 countsByYear W20729255272015 @default.
• W2072925527 countsByYear W20729255272016 @default.
• W2072925527 countsByYear W20729255272017 @default.
• W2072925527 countsByYear W20729255272018 @default.
• W2072925527 countsByYear W20729255272019 @default.
• W2072925527 countsByYear W20729255272021 @default.
• W2072925527 crossrefType "journal-article" @default.
• W2072925527 hasAuthorship W2072925527A5014885809 @default.
• W2072925527 hasAuthorship W2072925527A5046450925 @default.
• W2072925527 hasAuthorship W2072925527A5053170977 @default.
• W2072925527 hasBestOaLocation W20729255271 @default.
• W2072925527 hasConcept C104317684 @default.
• W2072925527 hasConcept C105795698 @default.
• W2072925527 hasConcept C107673813 @default.
• W2072925527 hasConcept C111350023 @default.
• W2072925527 hasConcept C119043178 @default.
• W2072925527 hasConcept C121608353 @default.
• W2072925527 hasConcept C144024400 @default.
• W2072925527 hasConcept C149782125 @default.
• W2072925527 hasConcept C149923435 @default.
• W2072925527 hasConcept C16012445 @default.
• W2072925527 hasConcept C161890455 @default.
• W2072925527 hasConcept C169594400 @default.
• W2072925527 hasConcept C177860879 @default.
• W2072925527 hasConcept C2908647359 @default.
• W2072925527 hasConcept C2992519594 @default.
• W2072925527 hasConcept C33923547 @default.
• W2072925527 hasConcept C530470458 @default.
• W2072925527 hasConcept C54355233 @default.
• W2072925527 hasConcept C71924100 @default.
• W2072925527 hasConcept C86803240 @default.
• W2072925527 hasConcept C99454951 @default.
• W2072925527 hasConceptScore W2072925527C104317684 @default.
• W2072925527 hasConceptScore W2072925527C105795698 @default.
• W2072925527 hasConceptScore W2072925527C107673813 @default.
• W2072925527 hasConceptScore W2072925527C111350023 @default.
• W2072925527 hasConceptScore W2072925527C119043178 @default.
• W2072925527 hasConceptScore W2072925527C121608353 @default.
• W2072925527 hasConceptScore W2072925527C144024400 @default.
• W2072925527 hasConceptScore W2072925527C149782125 @default.
• W2072925527 hasConceptScore W2072925527C149923435 @default.
• W2072925527 hasConceptScore W2072925527C16012445 @default.
• W2072925527 hasConceptScore W2072925527C161890455 @default.
• W2072925527 hasConceptScore W2072925527C169594400 @default.
• W2072925527 hasConceptScore W2072925527C177860879 @default.
• W2072925527 hasConceptScore W2072925527C2908647359 @default.
• W2072925527 hasConceptScore W2072925527C2992519594 @default.
• W2072925527 hasConceptScore W2072925527C33923547 @default.
• W2072925527 hasConceptScore W2072925527C530470458 @default.
• W2072925527 hasConceptScore W2072925527C54355233 @default.
• W2072925527 hasConceptScore W2072925527C71924100 @default.
• W2072925527 hasConceptScore W2072925527C86803240 @default.
• W2072925527 hasConceptScore W2072925527C99454951 @default.
• W2072925527 hasIssue "02" @default.
• W2072925527 hasLocation W20729255271 @default.
• W2072925527 hasLocation W20729255272 @default.

• next