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• W2072938446 abstract "Urinary tract infection (UTI) is the most common nonepidemic bacterial infection in humans, representing a constant danger for the host. Both innate and adaptive components of the immune system as well as stromal cells including bladder epithelium are involved in the prevention and clearance of UTI. However, the particular properties of the urogenital tract, which does not comprise typical physical barriers like a mucus or ciliated epithelium, necessitate soluble mediators with potent immunomodulatory capabilities. One candidate molecule capable of both mediating direct antimicrobial activity and alerting immune cells is the evolutionary conserved Tamm-Horsfall protein (THP). Tamm-Horsfall protein is exclusively produced by the kidney in the distal loop of Henle; however, its definite physiological function remains elusive. Mounting evidence indicates that beyond a mere direct antimicrobial activity, THP exerts potent immunoregulatory activity. Furthermore, the genetic ablation of the THP gene leads to severe infection and lethal pyelonephritis in an experimental model of UTI. Recent data are provided demonstrating that THP links the innate immune response with specific THP-directed cell-mediated immunity. In light of these novel findings we discuss the particular role of THP as a specialized defence molecule. We propose an integrated model of protective mechanisms against UTI where THP acts by two principle nonmutually exclusive mechanisms involving the capture of potentially dangerous microbes and the ability of this peculiar glycoprotein to induce robust protective immune responses against uropathogenic bacteria." @default.
• W2072938446 created "2016-06-24" @default.
• W2072938446 creator A5026988107 @default.
• W2072938446 creator A5038954546 @default.
• W2072938446 creator A5056030264 @default.
• W2072938446 creator A5058694170 @default.
• W2072938446 date "2005-04-01" @default.
• W2072938446 modified "2023-10-15" @default.
• W2072938446 title "Tamm-Horsfall protein: a multilayered defence molecule against urinary tract infection" @default.
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• W2072938446 doi "https://doi.org/10.1111/j.1365-2362.2005.01483.x" @default.
• W2072938446 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15816991" @default.
• W2072938446 hasPublicationYear "2005" @default.
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