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• W2072939107 abstract "Antiemetic effects of serotonin 5-HT3 receptor antagonists (ICS205-930, zacopride, BRL43694, GR38032F) were investigated in Suncus murinus. Veratrine, nicotine, copper sulfate, cisplatin, cyclophosphamide and motion sickness were used as emetic stimuli. Serotonin 5-HT3 receptor antagonists did not inhibit emetic responses to veratrine, nicotine, copper sulfate and motion sickness. However, cisplatin- and cyclophosphamide-induced emesis was strongly blocked by them. Both subcutaneous and intravenous injections of 5-HT3 antagonists were effective. Serotonin 5-HT1 and 5-HT2 receptor antagonists were less effective. These results clearly indicate that a 5-HT3 receptor-mediated mechanism(s) is involved in the emesis caused by cancer chemotherapeutic agents and that 5-HT3 receptor antagonists are very effective as prophylactic drugs." @default.
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• W2072939107 date "1991-01-01" @default.
• W2072939107 modified "2023-10-03" @default.
• W2072939107 title "Selective blockade of cytotoxic drug-induced emesis by 5-HT3 receptor antagonists in Suncus murinus." @default.
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• W2072939107 doi "https://doi.org/10.1254/jjp.55.107" @default.
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