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• W2072940897 abstract "Background & Aims Regular consumption of moderate amounts of Chinese yellow wine is associated with a reduced risk of coronary disease. Matrix metalloproteinases (MMPs) that participate in extracellular matrix degradation have been involved in atherosclerotic plaque growth and instability. The present research aimed to study the effects of Chinese yellow wine on the production of homocysteine (Hcy)-induced extracellular MMP-2 in cultured rats vascular smooth muscle cells (VSMCs). Methods We examined the effects of different Hcy levels (0–1000μmol/l) on MMP-2 production, and the effects of Chinese yellow wine with low alcohol concentrations (12–19%) on Hcy-induced MMP-2 in cultured rat (VSMCs) using gelatin zymography and western blotting. We further compared the changes of MMP-2 under various treatments for 12, 24 and 48h. Results Hcy (50–1000μmol/l) increased the production of MMP-2 significantly in a dose-dependent manner. Increased production of MMP-2 induced by Hcy was reduced by extracellularly added Chinese yellow wine. Production of MMP-2 under various treatments for 48h increased more than 12 and 24h. Conclusions Extracellularly added Chinese yellow wine decreased Hcy-induced MMP-2 secretion. The inhibitory effect of yellow wine on the activation of MMP-2 might contribute to their beneficial effects on the cardiovascular system." @default.
• W2072940897 created "2016-06-24" @default.
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• W2072940897 date "2007-06-01" @default.
• W2072940897 modified "2023-09-26" @default.
• W2072940897 title "Chinese yellow wine inhibits production of homocysteine-induced extracellular matrix metalloproteinase-2 in cultured rat vascular smooth muscle cells" @default.
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• W2072940897 doi "https://doi.org/10.1016/j.clnu.2007.01.007" @default.
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