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- W2072944060 abstract "There are many ways to present antigens to the immune system. We have used a repetitive antigen display technology that relies on the self-assembly of 60 protein chains into a spherical self-assembling protein nanoparticle (SAPN) to develop a vaccine against Plasmodium falciparum malaria. The protein sequence contains selected B- and T-cell epitopes of the circumsporozoite protein of P. falciparum (PfCSP) and, when assembled into a nanoparticle induces strong, long-lived and protective immune responses against the PfCSP. Here we describe the conditions needed for promoting self-assembly of a P. falciparum vaccine nanoparticle, PfCSP-KMY-SAPN, and note pitfalls that may occur when determining conditions for other SAPN vaccines. Attention was paid to selecting processes that were amenable to scale up and cGMP manufacturing." @default.
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- W2072944060 date "2013-05-01" @default.
- W2072944060 modified "2023-10-03" @default.
- W2072944060 title "Expression, purification and refolding of a self-assembling protein nanoparticle (SAPN) malaria vaccine" @default.
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- W2072944060 doi "https://doi.org/10.1016/j.ymeth.2013.03.025" @default.
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