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• W2072945029 startingPage "9776" @default.
• W2072945029 abstract "Quinolinone-3-carboxamide 1, a novel CFTR potentiator, was discovered using high-throughput screening in NIH-3T3 cells expressing the F508del-CFTR mutation. Extensive medicinal chemistry and iterative structure–activity relationship (SAR) studies to evaluate potency, selectivity, and pharmacokinetic properties resulted in the identification of N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide (VX-770, 48, ivacaftor), an investigational drug candidate approved by the FDA for the treatment of CF patients 6 years of age and older carrying the G551D mutation." @default.
• W2072945029 created "2016-06-24" @default.
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• W2072945029 date "2014-12-02" @default.
• W2072945029 modified "2023-10-14" @default.
• W2072945029 title "Discovery of <i>N</i>-(2,4-Di-<i>tert</i>-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide (VX-770, Ivacaftor), a Potent and Orally Bioavailable CFTR Potentiator" @default.
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• W2072945029 doi "https://doi.org/10.1021/jm5012808" @default.
• W2072945029 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25441013" @default.
• W2072945029 hasPublicationYear "2014" @default.
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