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• W2072945239 abstract "In this work, a novel and multifunctional nanocomposite of luminol capped gold modified Fe3O4 (Lu-AuNPs@Fe3O4) was utilized as the carrier of secondary antibody (Ab2) to fabricate a sandwiched electrochemiluminescence (ECL) immunosensor for ultrasensitive detection of mucin-1 (MUC1). Herein, the luminol capped gold nanoparticles (Lu-AuNPs) were synthesized with HAuCl4 and luminol by the help of NaBH4 at room temperature, and then Lu-AuNPs were adsorbed on the Fe3O4 magnetic nanoparticles (MNPs) to form the nanocomposite of Lu-AuNPs@Fe3O4 via electrostatic interaction. Fe3O4 MNPs in Lu-AuNPs@Fe3O4 exhibited excellent conductivity and admirable catalytic activity in H2O2 decomposition, which could enhance the ECL efficiency of luminol-H2O2 system. In addition, the substrates of gold coated ZnO nanoparticles (AuNPs@ZnO), providing large specific surface areas for primary antibody (Ab1) capturing, were modified on the electrode. As a result, a wide linear range of 7 orders of magnitude from 10 fg/mL to 10 ng/mL was obtained with an ultralow detection limit of 4.5 fg/mL for MUC1." @default.
• W2072945239 created "2016-06-24" @default.
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• W2072945239 date "2015-09-01" @default.
• W2072945239 modified "2023-10-18" @default.
• W2072945239 title "Electrochemiluminescence immunosensor based on multifunctional luminol-capped AuNPs@Fe 3 O 4 nanocomposite for the detection of mucin-1" @default.
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• W2072945239 doi "https://doi.org/10.1016/j.bios.2015.04.062" @default.
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