FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072947218> ?p ?o ?g. }

• W2072947218 endingPage "1696" @default.
• W2072947218 startingPage "1692" @default.
• W2072947218 abstract "<b>Objective:</b> The ε4 allele of the apolipoprotein E (ApoE) gene has been defined as a critical factor for early onset neurodegeneration in Pick’s, Parkinson’s, and Alzheimer’s disease. Unexpectedly, the ε4 allele appeared to delay the age of onset in Huntington’s disease (HD) patients. Furthermore, sex specific effects were reported on earlier age of onset due to the ApoE ε2ε3 genotype in males with HD. The age of onset of HD is known to be negatively correlated with increasing lengths of pathogenetic CAG expansions in the huntingtin gene. <b>Methods:</b> In order to examine the effects of CAG block lengths, we have correlated ApoE genotypes with the age of onset in 145 patients symptomatic for HD with psychiatric and somatic symptoms (depression, psychosis, dementia, choreic, and other movement disorders) harbouring only modestly expanded huntingtin alleles (41–45 CAGs). <b>Results:</b> The negative correlation between age of onset and CAG block length was established in our HD cohort. Statistically significant effects of the ε4 allele were not obvious regarding clinical characteristics including age of onset, nor were any sex differences for the ε2ε3 genotype observed. <b>Conclusion:</b> The ApoE genotype does not affect the course of HD significantly." @default.
• W2072947218 created "2016-06-24" @default.
• W2072947218 creator A5003780317 @default.
• W2072947218 creator A5025452509 @default.
• W2072947218 creator A5033072595 @default.
• W2072947218 creator A5037152965 @default.
• W2072947218 creator A5044775207 @default.
• W2072947218 creator A5052575530 @default.
• W2072947218 creator A5076423282 @default.
• W2072947218 date "2004-12-01" @default.
• W2072947218 modified "2023-09-26" @default.
• W2072947218 title "Apolipoprotein E genotypes do not influence the age of onset in Huntington's disease" @default.
• W2072947218 cites W1544063520 @default.
• W2072947218 cites W1548441884 @default.
• W2072947218 cites W1855728914 @default.
• W2072947218 cites W1964045427 @default.
• W2072947218 cites W1965271056 @default.
• W2072947218 cites W1968684036 @default.
• W2072947218 cites W1973055895 @default.
• W2072947218 cites W1999781602 @default.
• W2072947218 cites W2010475300 @default.
• W2072947218 cites W2021181758 @default.
• W2072947218 cites W2036362108 @default.
• W2072947218 cites W2044700035 @default.
• W2072947218 cites W2056127416 @default.
• W2072947218 cites W2058034919 @default.
• W2072947218 cites W2060191653 @default.
• W2072947218 cites W2084907056 @default.
• W2072947218 cites W2095123707 @default.
• W2072947218 cites W2121101037 @default.
• W2072947218 cites W2315335674 @default.
• W2072947218 cites W28897090 @default.
• W2072947218 cites W4292587951 @default.
• W2072947218 doi "https://doi.org/10.1136/jnnp.2003.022756" @default.
• W2072947218 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1738834" @default.
• W2072947218 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15548484" @default.
• W2072947218 hasPublicationYear "2004" @default.
• W2072947218 type Work @default.
• W2072947218 sameAs 2072947218 @default.
• W2072947218 citedByCount "29" @default.
• W2072947218 countsByYear W20729472182012 @default.
• W2072947218 countsByYear W20729472182013 @default.
• W2072947218 countsByYear W20729472182014 @default.
• W2072947218 countsByYear W20729472182015 @default.
• W2072947218 countsByYear W20729472182016 @default.
• W2072947218 countsByYear W20729472182018 @default.
• W2072947218 countsByYear W20729472182019 @default.
• W2072947218 countsByYear W20729472182020 @default.
• W2072947218 crossrefType "journal-article" @default.
• W2072947218 hasAuthorship W2072947218A5003780317 @default.
• W2072947218 hasAuthorship W2072947218A5025452509 @default.
• W2072947218 hasAuthorship W2072947218A5033072595 @default.
• W2072947218 hasAuthorship W2072947218A5037152965 @default.
• W2072947218 hasAuthorship W2072947218A5044775207 @default.
• W2072947218 hasAuthorship W2072947218A5052575530 @default.
• W2072947218 hasAuthorship W2072947218A5076423282 @default.
• W2072947218 hasBestOaLocation W20729472181 @default.
• W2072947218 hasConcept C104317684 @default.
• W2072947218 hasConcept C126322002 @default.
• W2072947218 hasConcept C134018914 @default.
• W2072947218 hasConcept C135763542 @default.
• W2072947218 hasConcept C15744967 @default.
• W2072947218 hasConcept C180754005 @default.
• W2072947218 hasConcept C2777767895 @default.
• W2072947218 hasConcept C2779134260 @default.
• W2072947218 hasConcept C2779483572 @default.
• W2072947218 hasConcept C2780647506 @default.
• W2072947218 hasConcept C2781427258 @default.
• W2072947218 hasConcept C54355233 @default.
• W2072947218 hasConcept C57089818 @default.
• W2072947218 hasConcept C71924100 @default.
• W2072947218 hasConcept C86803240 @default.
• W2072947218 hasConceptScore W2072947218C104317684 @default.
• W2072947218 hasConceptScore W2072947218C126322002 @default.
• W2072947218 hasConceptScore W2072947218C134018914 @default.
• W2072947218 hasConceptScore W2072947218C135763542 @default.
• W2072947218 hasConceptScore W2072947218C15744967 @default.
• W2072947218 hasConceptScore W2072947218C180754005 @default.
• W2072947218 hasConceptScore W2072947218C2777767895 @default.
• W2072947218 hasConceptScore W2072947218C2779134260 @default.
• W2072947218 hasConceptScore W2072947218C2779483572 @default.
• W2072947218 hasConceptScore W2072947218C2780647506 @default.
• W2072947218 hasConceptScore W2072947218C2781427258 @default.
• W2072947218 hasConceptScore W2072947218C54355233 @default.
• W2072947218 hasConceptScore W2072947218C57089818 @default.
• W2072947218 hasConceptScore W2072947218C71924100 @default.
• W2072947218 hasConceptScore W2072947218C86803240 @default.
• W2072947218 hasIssue "12" @default.
• W2072947218 hasLocation W20729472181 @default.
• W2072947218 hasLocation W20729472182 @default.
• W2072947218 hasLocation W20729472183 @default.
• W2072947218 hasLocation W20729472184 @default.
• W2072947218 hasOpenAccess W2072947218 @default.
• W2072947218 hasPrimaryLocation W20729472181 @default.
• W2072947218 hasRelatedWork W1855728914 @default.
• W2072947218 hasRelatedWork W2021756787 @default.
• W2072947218 hasRelatedWork W2072947218 @default.
• W2072947218 hasRelatedWork W2088809027 @default.

• next