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- W2072950733 abstract "Human papillomavirus (HPV) has evolved mechanisms that allow it to evade the human immune system. Studies have shown HPV-mediated suppression of activation of Langerhans cells (LC) is a key mechanism through which HPV16 evades initial immune surveillance. However, it has not been established whether high- and low-risk mucosal and cutaneous HPV genotypes share a common mechanism of immune suppression. Here, we demonstrate that LC exposed to capsids of HPV types 18, 31, 45, 11, (alpha-papillomaviruses) and HPV5 (beta-papillomavirus) similarly suppress LC activation, including lack of costimulatory molecule expression, lack of cytokine and chemokine secretion, lack of migration, and deregulated cellular signaling. In contrast, HPV1 (mu-papillomavirus) induced costimulatory molecule and cytokine upregulation, but LC migration and cellular signaling was suppressed. These results suggest that alpha and beta HPV genotypes, and partially a mu genotype, share a conserved mechanism of immune escape that enables these viruses to remain undetected in the absence of other inflammatory events." @default.
- W2072950733 created "2016-06-24" @default.
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- W2072950733 date "2014-03-01" @default.
- W2072950733 modified "2023-10-10" @default.
- W2072950733 title "Suppression of Langerhans cell activation is conserved amongst human papillomavirus α and β genotypes, but not a µ genotype" @default.
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- W2072950733 doi "https://doi.org/10.1016/j.virol.2014.01.031" @default.
- W2072950733 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3987942" @default.
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