FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072955125> ?p ?o ?g. }

• W2072955125 endingPage "784" @default.
• W2072955125 startingPage "781" @default.
• W2072955125 abstract "Polyethyleneimine (PEI) has been extensively investigated for use as a nonviral gene delivery vector due to its “proton sponge” mechanism. This work monitored the effect of PEGylation in vivo using nuclear imaging technique. We synthesized galactosylated PEI-PEG with different levels of PEG substitution ranging from 4.1 to 13.3 mol% of PEI amino groups. Validation of the differences of the in vivo distribution in the varying degrees of PEG substitution was performed using nuclear imaging with a gamma camera. PEGylated PEIs could easily label with reduced 99mTc because of their interaction with PEI amino groups. After systemic administration of 99mTc PEGylated Gal-PEIs, rapid accumulation in the liver, spleen, and lung was observed. However, with increasing amounts of PEG, the lung uptake was markedly reduced. These results demonstrate that nuclear imaging technique may be used as a basic screening tool for determining the optimized system of PEGylated Gal-PEIs. Once optimized, this system could be used as a hepatocyte targeted non-viral gene delivery vector which minimizes unspecific interactions with cellular blood components such as vessel endothelia and plasma proteins." @default.
• W2072955125 created "2016-06-24" @default.
• W2072955125 creator A5001737851 @default.
• W2072955125 creator A5017366073 @default.
• W2072955125 creator A5035737215 @default.
• W2072955125 creator A5053995401 @default.
• W2072955125 creator A5075411417 @default.
• W2072955125 creator A5079729400 @default.
• W2072955125 date "2004-08-01" @default.
• W2072955125 modified "2023-09-30" @default.
• W2072955125 title "Monitoring the effect of PEGylation on polyethylenimine in vivo using nuclear imaging technique" @default.
• W2072955125 cites W2009508594 @default.
• W2072955125 cites W2010655741 @default.
• W2072955125 cites W2037595752 @default.
• W2072955125 cites W2039467820 @default.
• W2072955125 cites W2044606823 @default.
• W2072955125 cites W2050932091 @default.
• W2072955125 cites W2074870430 @default.
• W2072955125 cites W2094913310 @default.
• W2072955125 cites W2106841282 @default.
• W2072955125 cites W2128800271 @default.
• W2072955125 cites W2142987628 @default.
• W2072955125 cites W2148919642 @default.
• W2072955125 cites W2313879875 @default.
• W2072955125 cites W353012429 @default.
• W2072955125 doi "https://doi.org/10.1016/j.nucmedbio.2004.03.006" @default.
• W2072955125 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15246369" @default.
• W2072955125 hasPublicationYear "2004" @default.
• W2072955125 type Work @default.
• W2072955125 sameAs 2072955125 @default.
• W2072955125 citedByCount "23" @default.
• W2072955125 countsByYear W20729551252012 @default.
• W2072955125 countsByYear W20729551252015 @default.
• W2072955125 countsByYear W20729551252016 @default.
• W2072955125 countsByYear W20729551252019 @default.
• W2072955125 countsByYear W20729551252020 @default.
• W2072955125 crossrefType "journal-article" @default.
• W2072955125 hasAuthorship W2072955125A5001737851 @default.
• W2072955125 hasAuthorship W2072955125A5017366073 @default.
• W2072955125 hasAuthorship W2072955125A5035737215 @default.
• W2072955125 hasAuthorship W2072955125A5053995401 @default.
• W2072955125 hasAuthorship W2072955125A5075411417 @default.
• W2072955125 hasAuthorship W2072955125A5079729400 @default.
• W2072955125 hasConcept C10138342 @default.
• W2072955125 hasConcept C104317684 @default.
• W2072955125 hasConcept C111599444 @default.
• W2072955125 hasConcept C12554922 @default.
• W2072955125 hasConcept C135983454 @default.
• W2072955125 hasConcept C136339569 @default.
• W2072955125 hasConcept C150903083 @default.
• W2072955125 hasConcept C162324750 @default.
• W2072955125 hasConcept C185592680 @default.
• W2072955125 hasConcept C207001950 @default.
• W2072955125 hasConcept C2775925850 @default.
• W2072955125 hasConcept C2776964284 @default.
• W2072955125 hasConcept C2779149719 @default.
• W2072955125 hasConcept C29331040 @default.
• W2072955125 hasConcept C54009773 @default.
• W2072955125 hasConcept C54400483 @default.
• W2072955125 hasConcept C55493867 @default.
• W2072955125 hasConcept C86803240 @default.
• W2072955125 hasConceptScore W2072955125C10138342 @default.
• W2072955125 hasConceptScore W2072955125C104317684 @default.
• W2072955125 hasConceptScore W2072955125C111599444 @default.
• W2072955125 hasConceptScore W2072955125C12554922 @default.
• W2072955125 hasConceptScore W2072955125C135983454 @default.
• W2072955125 hasConceptScore W2072955125C136339569 @default.
• W2072955125 hasConceptScore W2072955125C150903083 @default.
• W2072955125 hasConceptScore W2072955125C162324750 @default.
• W2072955125 hasConceptScore W2072955125C185592680 @default.
• W2072955125 hasConceptScore W2072955125C207001950 @default.
• W2072955125 hasConceptScore W2072955125C2775925850 @default.
• W2072955125 hasConceptScore W2072955125C2776964284 @default.
• W2072955125 hasConceptScore W2072955125C2779149719 @default.
• W2072955125 hasConceptScore W2072955125C29331040 @default.
• W2072955125 hasConceptScore W2072955125C54009773 @default.
• W2072955125 hasConceptScore W2072955125C54400483 @default.
• W2072955125 hasConceptScore W2072955125C55493867 @default.
• W2072955125 hasConceptScore W2072955125C86803240 @default.
• W2072955125 hasIssue "6" @default.
• W2072955125 hasLocation W20729551251 @default.
• W2072955125 hasLocation W20729551252 @default.
• W2072955125 hasOpenAccess W2072955125 @default.
• W2072955125 hasPrimaryLocation W20729551251 @default.
• W2072955125 hasRelatedWork W2003504471 @default.
• W2072955125 hasRelatedWork W2013482618 @default.
• W2072955125 hasRelatedWork W2048456201 @default.
• W2072955125 hasRelatedWork W2072955125 @default.
• W2072955125 hasRelatedWork W2080287503 @default.
• W2072955125 hasRelatedWork W2300713937 @default.
• W2072955125 hasRelatedWork W2329072538 @default.
• W2072955125 hasRelatedWork W2363676239 @default.
• W2072955125 hasRelatedWork W2800121303 @default.
• W2072955125 hasRelatedWork W779935921 @default.
• W2072955125 hasVolume "31" @default.
• W2072955125 isParatext "false" @default.
• W2072955125 isRetracted "false" @default.
• W2072955125 magId "2072955125" @default.

• next