Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072955903> ?p ?o ?g. }
- W2072955903 endingPage "73" @default.
- W2072955903 startingPage "59" @default.
- W2072955903 abstract "The binding of nicotinamide--adenine dinucleotide (NAD+), nicotinamide--1,N6-ethenoadenine dinucleotide (epsilon NAD+), acetylpyridine--adenine dinucleotide (AcPyAD+), ATP, and adenosine diphosphoribose (ADP-ribose) to rabbit muscle glyceraldehyde-3-phosphate dehydrogenase (the enzyme) was examined. NAD+ and epsilon NAD+ were found to bind to the apoenzyme in a negatively cooperative manner, whereas AcPyAD+, ATP, and ADP-ribose bind non-cooperatively to the NAD+ sites. The strong negative cooperativity in coenzyme binding was found to be abolished in the presence of AcPyAD+ and strongly weakened by ATP, ADP, and AMP, but was not affected by the addition of ADP-ribose. These findings demonstrate that the mechanism of the negative cooperativity in coenzyme binding to the enzyme involves ligand-induced conformational changes between neighboring sites. These findings cannot be accounted for by the pre-existent asymmetry model. The results support our previous hypothesis that the structure of the pyridine moiety of the coenzyme analogues plays a role in orienting the adenine moiety in the adenine subsite, and thus affects the cooperativity observed in the binding of the coenzyme analogue." @default.
- W2072955903 created "2016-06-24" @default.
- W2072955903 creator A5004637588 @default.
- W2072955903 creator A5086404962 @default.
- W2072955903 date "1980-11-01" @default.
- W2072955903 modified "2023-09-24" @default.
- W2072955903 title "The Sequential Nature of the Negative Cooperativity in Rabbit Muscle Glyceraldehyde-3-Phosphate Dehydrogenase" @default.
- W2072955903 cites W1494932755 @default.
- W2072955903 cites W1513843435 @default.
- W2072955903 cites W1520698553 @default.
- W2072955903 cites W1524786741 @default.
- W2072955903 cites W1545637156 @default.
- W2072955903 cites W1567978253 @default.
- W2072955903 cites W1587913679 @default.
- W2072955903 cites W1641120577 @default.
- W2072955903 cites W1856298316 @default.
- W2072955903 cites W1983649348 @default.
- W2072955903 cites W1992828913 @default.
- W2072955903 cites W2003867304 @default.
- W2072955903 cites W2005392755 @default.
- W2072955903 cites W2009652285 @default.
- W2072955903 cites W2014902405 @default.
- W2072955903 cites W2015908212 @default.
- W2072955903 cites W2016291266 @default.
- W2072955903 cites W2023525245 @default.
- W2072955903 cites W2029122738 @default.
- W2072955903 cites W2030388917 @default.
- W2072955903 cites W2032002530 @default.
- W2072955903 cites W2034201485 @default.
- W2072955903 cites W2035070135 @default.
- W2072955903 cites W2035129784 @default.
- W2072955903 cites W2049704085 @default.
- W2072955903 cites W2059790486 @default.
- W2072955903 cites W2061545032 @default.
- W2072955903 cites W2061608860 @default.
- W2072955903 cites W2066105436 @default.
- W2072955903 cites W2066954723 @default.
- W2072955903 cites W2067439431 @default.
- W2072955903 cites W2075345465 @default.
- W2072955903 cites W2076309454 @default.
- W2072955903 cites W2090186346 @default.
- W2072955903 cites W2093702158 @default.
- W2072955903 cites W2094427703 @default.
- W2072955903 cites W2138392605 @default.
- W2072955903 cites W220305778 @default.
- W2072955903 cites W2361758836 @default.
- W2072955903 cites W2413154211 @default.
- W2072955903 cites W2987340021 @default.
- W2072955903 cites W4076929 @default.
- W2072955903 cites W4246090926 @default.
- W2072955903 cites W7325074 @default.
- W2072955903 cites W98494768 @default.
- W2072955903 doi "https://doi.org/10.1111/j.1432-1033.1980.tb04987.x" @default.
- W2072955903 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7449764" @default.
- W2072955903 hasPublicationYear "1980" @default.
- W2072955903 type Work @default.
- W2072955903 sameAs 2072955903 @default.
- W2072955903 citedByCount "24" @default.
- W2072955903 countsByYear W20729559032015 @default.
- W2072955903 countsByYear W20729559032017 @default.
- W2072955903 crossrefType "journal-article" @default.
- W2072955903 hasAuthorship W2072955903A5004637588 @default.
- W2072955903 hasAuthorship W2072955903A5086404962 @default.
- W2072955903 hasBestOaLocation W20729559031 @default.
- W2072955903 hasConcept C134792803 @default.
- W2072955903 hasConcept C166014724 @default.
- W2072955903 hasConcept C166342909 @default.
- W2072955903 hasConcept C181199279 @default.
- W2072955903 hasConcept C185592680 @default.
- W2072955903 hasConcept C187250156 @default.
- W2072955903 hasConcept C197957613 @default.
- W2072955903 hasConcept C2776317432 @default.
- W2072955903 hasConcept C2776568683 @default.
- W2072955903 hasConcept C2776901170 @default.
- W2072955903 hasConcept C2777989768 @default.
- W2072955903 hasConcept C2779461342 @default.
- W2072955903 hasConcept C2779728014 @default.
- W2072955903 hasConcept C38485361 @default.
- W2072955903 hasConcept C55493867 @default.
- W2072955903 hasConcept C71240020 @default.
- W2072955903 hasConcept C75520062 @default.
- W2072955903 hasConceptScore W2072955903C134792803 @default.
- W2072955903 hasConceptScore W2072955903C166014724 @default.
- W2072955903 hasConceptScore W2072955903C166342909 @default.
- W2072955903 hasConceptScore W2072955903C181199279 @default.
- W2072955903 hasConceptScore W2072955903C185592680 @default.
- W2072955903 hasConceptScore W2072955903C187250156 @default.
- W2072955903 hasConceptScore W2072955903C197957613 @default.
- W2072955903 hasConceptScore W2072955903C2776317432 @default.
- W2072955903 hasConceptScore W2072955903C2776568683 @default.
- W2072955903 hasConceptScore W2072955903C2776901170 @default.
- W2072955903 hasConceptScore W2072955903C2777989768 @default.
- W2072955903 hasConceptScore W2072955903C2779461342 @default.
- W2072955903 hasConceptScore W2072955903C2779728014 @default.
- W2072955903 hasConceptScore W2072955903C38485361 @default.
- W2072955903 hasConceptScore W2072955903C55493867 @default.
- W2072955903 hasConceptScore W2072955903C71240020 @default.
- W2072955903 hasConceptScore W2072955903C75520062 @default.