Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072956069> ?p ?o ?g. }
- W2072956069 endingPage "1196" @default.
- W2072956069 startingPage "1183" @default.
- W2072956069 abstract "One potential mechanism of temporal lobe epilepsy is recurrent excitation of dentate granule cells through aberrant sprouting of their axons (mossy fibers), which is found in many patients and animal models. However, correlations between the extent of mossy fiber sprouting and seizure frequency are weak. Additional potential sources of granule cell recurrent excitation that would not have been detected by markers of mossy fiber sprouting in previous studies include surviving mossy cells and proximal CA3 pyramidal cells. To test those possibilities in hippocampal slices from epileptic pilocarpine-treated rats, laser-scanning glutamate uncaging was used to randomly and focally activate neurons in the granule cell layer, hilus, and proximal CA3 pyramidal cell layer while measuring evoked EPSCs in normotopic granule cells. Consistent with mossy fiber sprouting, a higher proportion of glutamate-uncaging spots in the granule cell layer evoked EPSCs in epileptic rats compared with controls. In addition, stimulation spots in the hilus and proximal CA3 pyramidal cell layer were more likely to evoke EPSCs in epileptic rats, despite significant neuron loss in those regions. Furthermore, synaptic strength of recurrent excitatory inputs to granule cells from CA3 pyramidal cells and other granule cells was increased in epileptic rats. These findings reveal substantial levels of excessive, recurrent, excitatory synaptic input to granule cells from neurons in the hilus and proximal CA3 field. The aberrant development of these additional positive-feedback circuits might contribute to epileptogenesis in temporal lobe epilepsy." @default.
- W2072956069 created "2016-06-24" @default.
- W2072956069 creator A5017440715 @default.
- W2072956069 creator A5033400284 @default.
- W2072956069 creator A5043443793 @default.
- W2072956069 date "2012-01-25" @default.
- W2072956069 modified "2023-10-02" @default.
- W2072956069 title "Increased Excitatory Synaptic Input to Granule Cells from Hilar and CA3 Regions in a Rat Model of Temporal Lobe Epilepsy" @default.
- W2072956069 cites W1483619155 @default.
- W2072956069 cites W1506123947 @default.
- W2072956069 cites W1585349385 @default.
- W2072956069 cites W1588358470 @default.
- W2072956069 cites W1703482695 @default.
- W2072956069 cites W1723579215 @default.
- W2072956069 cites W1827373965 @default.
- W2072956069 cites W1880862139 @default.
- W2072956069 cites W1883162734 @default.
- W2072956069 cites W1906116459 @default.
- W2072956069 cites W1966755346 @default.
- W2072956069 cites W1968455958 @default.
- W2072956069 cites W1968586112 @default.
- W2072956069 cites W1971275801 @default.
- W2072956069 cites W1976017704 @default.
- W2072956069 cites W1979198709 @default.
- W2072956069 cites W1981210508 @default.
- W2072956069 cites W1981558401 @default.
- W2072956069 cites W1983635597 @default.
- W2072956069 cites W1983665651 @default.
- W2072956069 cites W1988199645 @default.
- W2072956069 cites W1988344748 @default.
- W2072956069 cites W1988819522 @default.
- W2072956069 cites W1993891869 @default.
- W2072956069 cites W1995054278 @default.
- W2072956069 cites W1998797350 @default.
- W2072956069 cites W1999151021 @default.
- W2072956069 cites W1999874178 @default.
- W2072956069 cites W2000040515 @default.
- W2072956069 cites W2003834071 @default.
- W2072956069 cites W2005904236 @default.
- W2072956069 cites W2006383186 @default.
- W2072956069 cites W2006985248 @default.
- W2072956069 cites W2009093172 @default.
- W2072956069 cites W2010866903 @default.
- W2072956069 cites W2012132665 @default.
- W2072956069 cites W2013965696 @default.
- W2072956069 cites W2015047283 @default.
- W2072956069 cites W2018749736 @default.
- W2072956069 cites W2023588733 @default.
- W2072956069 cites W2028217587 @default.
- W2072956069 cites W2029826897 @default.
- W2072956069 cites W2033062600 @default.
- W2072956069 cites W2035562497 @default.
- W2072956069 cites W2035975399 @default.
- W2072956069 cites W2038465691 @default.
- W2072956069 cites W2040534171 @default.
- W2072956069 cites W2040821610 @default.
- W2072956069 cites W2040851668 @default.
- W2072956069 cites W2042315877 @default.
- W2072956069 cites W2045009795 @default.
- W2072956069 cites W2051064821 @default.
- W2072956069 cites W2051818217 @default.
- W2072956069 cites W2053358664 @default.
- W2072956069 cites W2055625569 @default.
- W2072956069 cites W2058169953 @default.
- W2072956069 cites W2058512861 @default.
- W2072956069 cites W2059521678 @default.
- W2072956069 cites W2060519895 @default.
- W2072956069 cites W2062602488 @default.
- W2072956069 cites W2065412452 @default.
- W2072956069 cites W2065662771 @default.
- W2072956069 cites W2065962088 @default.
- W2072956069 cites W2067775848 @default.
- W2072956069 cites W2070042187 @default.
- W2072956069 cites W2070864731 @default.
- W2072956069 cites W2073182614 @default.
- W2072956069 cites W2075830803 @default.
- W2072956069 cites W2076302671 @default.
- W2072956069 cites W2078356996 @default.
- W2072956069 cites W2083146047 @default.
- W2072956069 cites W2083479482 @default.
- W2072956069 cites W2083545427 @default.
- W2072956069 cites W2087592242 @default.
- W2072956069 cites W2091160631 @default.
- W2072956069 cites W2091441008 @default.
- W2072956069 cites W2097637304 @default.
- W2072956069 cites W2101703484 @default.
- W2072956069 cites W2102137096 @default.
- W2072956069 cites W2103946141 @default.
- W2072956069 cites W2114519398 @default.
- W2072956069 cites W2120839782 @default.
- W2072956069 cites W2122623728 @default.
- W2072956069 cites W2125390340 @default.
- W2072956069 cites W2128491503 @default.
- W2072956069 cites W2131705496 @default.
- W2072956069 cites W2150936467 @default.
- W2072956069 cites W2159475829 @default.
- W2072956069 cites W2159734026 @default.
- W2072956069 cites W2165137690 @default.