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• W2072959295 endingPage "62" @default.
• W2072959295 startingPage "46" @default.
• W2072959295 abstract "At focal CNS injury sites, several cytokines accumulate, including ciliary neurotrophic factor (CNTF) and interleukin-1β (IL-1β). Additionally, the CNTF alpha receptor is induced on astrocytes, establishing an autocrine/paracrine loop. How astrocyte function is altered as a result of CNTF stimulation remains incompletely characterized. Here, we demonstrate that direct injection of CNTF into the spinal cord increases GFAP expression and astroglial size and that primary cultures of spinal cord astrocytes treated with CNTF, IL-1β, or leukemia inhibitory factor exhibit nuclear hypertrophy comparable to that observed in vivo. Using a coculture bioassay, we further demonstrate that CNTF treatment of astrocytes increases their ability to support ChAT+ ventral spinal cord neurons (presumably motor neurons) more than twofold compared with untreated astrocytes. Also, the complexity of neurites was significantly increased in neurons cultured with CNTF-treated astrocytes compared with untreated astrocytes. RT–PCR analysis demonstrated that CNTF increased levels of FGF-2 and nerve growth factor (NGF) mRNA and that IL-1β increased NGF and hepatocyte growth factor mRNA levels. Furthermore, both CNTF and IL-1β stimulated the release of FGF-2 from cultured spinal cord astrocytes. These findings demonstrate that cytokine-activated astrocytes better support CNS neuron survival via the production of neurotrophic molecules. We also show that CNTF synergizes with FGF-2, but not epidermal growth factor, to promote DNA synthesis in spinal cord astrocyte cultures. The significance of these findings is discussed by presenting a new model depicting the sequential activation of astrocytes by cytokines and growth factors in the context of CNS injury and repair." @default.
• W2072959295 created "2016-06-24" @default.
• W2072959295 creator A5005833478 @default.
• W2072959295 creator A5012313326 @default.
• W2072959295 creator A5045036566 @default.
• W2072959295 creator A5065822870 @default.
• W2072959295 creator A5091603108 @default.
• W2072959295 date "2002-01-01" @default.
• W2072959295 modified "2023-09-28" @default.
• W2072959295 title "Ciliary Neurotrophic Factor Activates Spinal Cord Astrocytes, Stimulating Their Production and Release of Fibroblast Growth Factor-2, to Increase Motor Neuron Survival" @default.
• W2072959295 cites W1024952871 @default.
• W2072959295 cites W1482686873 @default.
• W2072959295 cites W1510804202 @default.
• W2072959295 cites W1517125774 @default.
• W2072959295 cites W1635850624 @default.
• W2072959295 cites W1636162490 @default.
• W2072959295 cites W1805673099 @default.
• W2072959295 cites W1826049628 @default.
• W2072959295 cites W1831896177 @default.
• W2072959295 cites W1971668430 @default.
• W2072959295 cites W1973061682 @default.
• W2072959295 cites W1974356135 @default.
• W2072959295 cites W1974521776 @default.
• W2072959295 cites W1976760754 @default.
• W2072959295 cites W1978430917 @default.
• W2072959295 cites W1979024805 @default.
• W2072959295 cites W1980054254 @default.
• W2072959295 cites W1980122698 @default.
• W2072959295 cites W1980144255 @default.
• W2072959295 cites W1981837304 @default.
• W2072959295 cites W1983317203 @default.
• W2072959295 cites W1983557415 @default.
• W2072959295 cites W1984100204 @default.
• W2072959295 cites W1984457610 @default.
• W2072959295 cites W1984689716 @default.
• W2072959295 cites W1992559673 @default.
• W2072959295 cites W1996159903 @default.
• W2072959295 cites W2006207066 @default.
• W2072959295 cites W2006289803 @default.
• W2072959295 cites W2011210247 @default.
• W2072959295 cites W2012172513 @default.
• W2072959295 cites W2013271691 @default.
• W2072959295 cites W2013707288 @default.
• W2072959295 cites W2014744948 @default.
• W2072959295 cites W2016174500 @default.
• W2072959295 cites W2016237837 @default.
• W2072959295 cites W2020122762 @default.
• W2072959295 cites W2023711051 @default.
• W2072959295 cites W2024081088 @default.
• W2072959295 cites W2025199687 @default.
• W2072959295 cites W2027443989 @default.
• W2072959295 cites W2027617017 @default.
• W2072959295 cites W2028531700 @default.
• W2072959295 cites W2029392153 @default.
• W2072959295 cites W2030789321 @default.
• W2072959295 cites W2031167408 @default.
• W2072959295 cites W2033494272 @default.
• W2072959295 cites W2033769657 @default.
• W2072959295 cites W2042465454 @default.
• W2072959295 cites W2043585611 @default.
• W2072959295 cites W2045885390 @default.
• W2072959295 cites W2047426662 @default.
• W2072959295 cites W2048396840 @default.
• W2072959295 cites W2055509532 @default.
• W2072959295 cites W205599847 @default.
• W2072959295 cites W2058140538 @default.
• W2072959295 cites W2062994385 @default.
• W2072959295 cites W2067692195 @default.
• W2072959295 cites W2071717171 @default.
• W2072959295 cites W2074695265 @default.
• W2072959295 cites W2077779305 @default.
• W2072959295 cites W2082619657 @default.
• W2072959295 cites W2084287845 @default.
• W2072959295 cites W2084344896 @default.
• W2072959295 cites W2085327078 @default.
• W2072959295 cites W2089741801 @default.
• W2072959295 cites W2090940022 @default.
• W2072959295 cites W2091896481 @default.
• W2072959295 cites W2091898207 @default.
• W2072959295 cites W2092184932 @default.
• W2072959295 cites W2097530133 @default.
• W2072959295 cites W2099976535 @default.
• W2072959295 cites W2101808673 @default.
• W2072959295 cites W2102093684 @default.
• W2072959295 cites W2106829291 @default.
• W2072959295 cites W2122400789 @default.
• W2072959295 cites W2127338217 @default.
• W2072959295 cites W2127838140 @default.
• W2072959295 cites W2137973944 @default.
• W2072959295 cites W2139567376 @default.
• W2072959295 cites W2153179483 @default.
• W2072959295 cites W2158406932 @default.
• W2072959295 cites W2266209009 @default.
• W2072959295 cites W2319643017 @default.
• W2072959295 cites W2327562877 @default.
• W2072959295 cites W2437818877 @default.
• W2072959295 cites W4211063301 @default.
• W2072959295 cites W4236776779 @default.

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