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- W2072960228 abstract "Cultured bovine aortic smooth muscle and endothelial cells each display distinct specific binding sites for radiolabeled atrial natriuretic peptide (ANF). 125I-pro-rANF (103–126)1 binding to both cell types is rapid, reversible and competitive. Scatchard plots of the binding data show Bmax values of 5.5 and 0.1 – 2.1 × 105 sites/cell and Kd values of 2.1 and 0.3 nM for smooth muscle and endothelial cells, respectively. In addition, ANF elevates levels of cGMP substantially in both cell types at concentrations of ANF close to its Kd and Ki for binding. Sodium nitroprusside, however, has essentially no effect on cGMP levels in either cell type. These results show that distinct functionally active receptor sites for ANF exist on both vascular smooth muscle and endothelial cells." @default.
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- W2072960228 date "1985-03-01" @default.
- W2072960228 modified "2023-10-18" @default.
- W2072960228 title "Distinct atrial natriuretic factor receptor sites on cultured bovine aortic smooth muscle and endothelial cells" @default.
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- W2072960228 doi "https://doi.org/10.1016/s0006-291x(85)80179-0" @default.
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