FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072963105> ?p ?o ?g. }

• W2072963105 endingPage "494" @default.
• W2072963105 startingPage "488" @default.
• W2072963105 abstract "Down syndrome (DS) is the most frequent genetic cause of mental retardation (MR) associated with neurological alterations. To allow a genetic dissection of DS phenotype, we studied eight transgenic mouse lines carrying YACs containing human DNA fragments covering DS critical region (DCR-1), as an in vivo library. Herein, we found an increased brain size in the 152F7-mice containing DYRK1A gene. We also identified a new cerebellar alteration in two independent lines carrying 230E8-YAC. These mice showed significant elongation of the cerebellar antero-posterior axis (p < 0.001), determined by increased length of rostral folia of the vermis (lobule II–V, p < 0.0001; lobule VI, p < 0.001). In addition, we identified a major neurological defect in culmen and declivus lobules in the 230E8-mice. We analyzed P30, P12, and P9 stages and detected high significant increased lengths of anterior lobules (II–VI) of 230E8-mice at P30 and P12 (lobule II–V, p < 0.0001; lobule VI, p < 0.05), but not at P9, indicating that this new phenotype appears between P9 and P12. Interestingly, 230E8-mice also present increased cortical cell density and mild learning defects. 230E8-YAC contains seven genes, some of which could be potentially responsible for this phenotype. Between them, we proposed DOPEY2 as potential candidate gene for these cerebellar alterations considering its high expression in the brain and that its homologous genes in yeast, Caenorhabditis elegans and Drosophila are involved in morphogenesis, suggesting a conserved role of DOPEY2 as a patterning gene." @default.
• W2072963105 created "2016-06-24" @default.
• W2072963105 creator A5003912204 @default.
• W2072963105 creator A5014218977 @default.
• W2072963105 creator A5016631919 @default.
• W2072963105 creator A5016823725 @default.
• W2072963105 creator A5051619512 @default.
• W2072963105 creator A5063952608 @default.
• W2072963105 date "2007-12-01" @default.
• W2072963105 modified "2023-09-26" @default.
• W2072963105 title "New cerebellar phenotypes in YAC transgenic mouse in vivo library of human Down syndrome critical region-1" @default.
• W2072963105 cites W1570744085 @default.
• W2072963105 cites W1860217789 @default.
• W2072963105 cites W1963835115 @default.
• W2072963105 cites W1964541915 @default.
• W2072963105 cites W1968338739 @default.
• W2072963105 cites W1974428682 @default.
• W2072963105 cites W1984976614 @default.
• W2072963105 cites W1985210410 @default.
• W2072963105 cites W1997381668 @default.
• W2072963105 cites W1999789975 @default.
• W2072963105 cites W2001324648 @default.
• W2072963105 cites W2001653133 @default.
• W2072963105 cites W2018626472 @default.
• W2072963105 cites W2019377841 @default.
• W2072963105 cites W2038934257 @default.
• W2072963105 cites W2040150222 @default.
• W2072963105 cites W2050959988 @default.
• W2072963105 cites W2064358122 @default.
• W2072963105 cites W2080464254 @default.
• W2072963105 cites W2093793347 @default.
• W2072963105 cites W2094693394 @default.
• W2072963105 cites W2111937069 @default.
• W2072963105 cites W2119800709 @default.
• W2072963105 cites W2122456436 @default.
• W2072963105 cites W2142250724 @default.
• W2072963105 cites W2149852014 @default.
• W2072963105 cites W2153338937 @default.
• W2072963105 cites W2166546867 @default.
• W2072963105 cites W2194629139 @default.
• W2072963105 cites W2347208728 @default.
• W2072963105 cites W2404690351 @default.
• W2072963105 cites W4239383780 @default.
• W2072963105 doi "https://doi.org/10.1016/j.bbrc.2007.10.035" @default.
• W2072963105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17963726" @default.
• W2072963105 hasPublicationYear "2007" @default.
• W2072963105 type Work @default.
• W2072963105 sameAs 2072963105 @default.
• W2072963105 citedByCount "13" @default.
• W2072963105 countsByYear W20729631052012 @default.
• W2072963105 countsByYear W20729631052013 @default.
• W2072963105 countsByYear W20729631052014 @default.
• W2072963105 countsByYear W20729631052017 @default.
• W2072963105 countsByYear W20729631052018 @default.
• W2072963105 countsByYear W20729631052020 @default.
• W2072963105 countsByYear W20729631052023 @default.
• W2072963105 crossrefType "journal-article" @default.
• W2072963105 hasAuthorship W2072963105A5003912204 @default.
• W2072963105 hasAuthorship W2072963105A5014218977 @default.
• W2072963105 hasAuthorship W2072963105A5016631919 @default.
• W2072963105 hasAuthorship W2072963105A5016823725 @default.
• W2072963105 hasAuthorship W2072963105A5051619512 @default.
• W2072963105 hasAuthorship W2072963105A5063952608 @default.
• W2072963105 hasConcept C102230213 @default.
• W2072963105 hasConcept C104317684 @default.
• W2072963105 hasConcept C127716648 @default.
• W2072963105 hasConcept C134018914 @default.
• W2072963105 hasConcept C141035611 @default.
• W2072963105 hasConcept C153911025 @default.
• W2072963105 hasConcept C2778944004 @default.
• W2072963105 hasConcept C2779652256 @default.
• W2072963105 hasConcept C40692019 @default.
• W2072963105 hasConcept C54355233 @default.
• W2072963105 hasConcept C86803240 @default.
• W2072963105 hasConcept C95444343 @default.
• W2072963105 hasConceptScore W2072963105C102230213 @default.
• W2072963105 hasConceptScore W2072963105C104317684 @default.
• W2072963105 hasConceptScore W2072963105C127716648 @default.
• W2072963105 hasConceptScore W2072963105C134018914 @default.
• W2072963105 hasConceptScore W2072963105C141035611 @default.
• W2072963105 hasConceptScore W2072963105C153911025 @default.
• W2072963105 hasConceptScore W2072963105C2778944004 @default.
• W2072963105 hasConceptScore W2072963105C2779652256 @default.
• W2072963105 hasConceptScore W2072963105C40692019 @default.
• W2072963105 hasConceptScore W2072963105C54355233 @default.
• W2072963105 hasConceptScore W2072963105C86803240 @default.
• W2072963105 hasConceptScore W2072963105C95444343 @default.
• W2072963105 hasIssue "3" @default.
• W2072963105 hasLocation W20729631051 @default.
• W2072963105 hasLocation W20729631052 @default.
• W2072963105 hasOpenAccess W2072963105 @default.
• W2072963105 hasPrimaryLocation W20729631051 @default.
• W2072963105 hasRelatedWork W1809349505 @default.
• W2072963105 hasRelatedWork W1920402565 @default.
• W2072963105 hasRelatedWork W1946787458 @default.
• W2072963105 hasRelatedWork W2013060082 @default.
• W2072963105 hasRelatedWork W2111634467 @default.
• W2072963105 hasRelatedWork W2123876128 @default.

• next