FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072963128> ?p ?o ?g. }

• W2072963128 endingPage "566" @default.
• W2072963128 startingPage "566" @default.
• W2072963128 abstract "Aim: The vasculopathic impact of homocysteine (HCy) is mediated through the generation of superoxide, a phenomenon augmented by copper (Cu2+). Cardiopulmonary bypass (CPB) also elicits oxidant stress. Since oxygen free radicals may play a role in both early and late vein graft failure, the blood levels of HCy and Cu2+ and related parameters, before and after surgery, were investigated in patients undergoing coronary artery bypass graft surgery (CABG), both with (on pump) and without CPB (off pump). Methods: Blood samples were taken from 20 consecutive patients (10 on-pump and 10 off-pump) undergoing CABG, one day pre-operatively (D0) and one day (D1) and six days (D6) post-operatively. Plasma HCy, serum Cu2+, caeruloplasmin (CP) and vitamin B12 and red cell folate were then measured. Results: Pre-operative (D0) plasma concentrations of HCy were below the accepted risk factor value of 14 μmol/l. At D1 there was a reduction in all parameters in both groups, which is ascribable to hemodilution. However, in both on pump and off pump groups, HCy, Cu2+ and CP were all significantly increased at D6. Concentrations of red cell folate were not significantly altered and serum vitamin B12 was significantly increased at D6, indicating that the increase in HCy was not due to a reduction in these vitamins. When comparing on-pump to off pump, there were no significant differences between any parameter except for Cu2+ which was significantly greater in the on pump group compared to the off pump group at D6. Table 1. Circulating Parameters Following CABG (Means ± SEM; n = 10 ) *p < 0.05 vs Pre-Operative Levels and #p < 0.05 on Pump vs Off Pump HCy (μmol/l) Cu2+ (μmol/l) CP (g/l) Folate (mg/l) VitB12 (ng/l) On pump: D0 10.5 ± 1.3 13.9 ± 3.2 0.30 ± 0.05 388 ± 182 261 ± 75 Off pump: D0 9.8 ± 1.2 13.6 ± 3.3 0.35 ± 0.12 340 ± 78 240 ± 140 On pump: D1 9.2 ± 1.4 10.5 ± 3.2 0.23 ± 0.10 357 ± 168 170 ± 62 Off pump: D1 8.7 ± 1.3 13.2 ± 2.8 0.32 ± 0.10 351 ± 84 190 ± 89 On pump: D6 12.7 ± 1.2* 21.9 ± 2.5*# 0.40 ± 0.04* 394 ± 150 410 ± 160* Off pump: D6 11.1 ± 1.3* 19.0 ± 2.6* 0.40 ± 0.07* 331 ± 57 385 ± 169* Conclusions: Contrary to other reports, the pre-operative plasma concentrations of HCy in this study suggest that HCy is not a risk factor for coronary artery disease. However, following CABG, the significant increase in HCy and Cu2+ may be of pathological importance since Cu2+ augments the release of superoxide from HCy. The greater increase in serum Cu2+ in the on-pump group indicates that CPB may promote oxidant stress through elevation of this potent transition metal." @default.
• W2072963128 created "2016-06-24" @default.
• W2072963128 creator A5000096606 @default.
• W2072963128 creator A5006478312 @default.
• W2072963128 creator A5011226884 @default.
• W2072963128 creator A5034873502 @default.
• W2072963128 creator A5054764500 @default.
• W2072963128 creator A5059405540 @default.
• W2072963128 creator A5067196342 @default.
• W2072963128 date "2002-11-01" @default.
• W2072963128 modified "2023-09-23" @default.
• W2072963128 title "Circulating Homocysteine and Copper Following Coronary Artery Bypass Graft Surgery with and Without Cardiopulmonary Bypass" @default.
• W2072963128 doi "https://doi.org/10.1046/j.1540-8191.2002.101425.x" @default.
• W2072963128 hasPublicationYear "2002" @default.
• W2072963128 type Work @default.
• W2072963128 sameAs 2072963128 @default.
• W2072963128 citedByCount "0" @default.
• W2072963128 crossrefType "journal-article" @default.
• W2072963128 hasAuthorship W2072963128A5000096606 @default.
• W2072963128 hasAuthorship W2072963128A5006478312 @default.
• W2072963128 hasAuthorship W2072963128A5011226884 @default.
• W2072963128 hasAuthorship W2072963128A5034873502 @default.
• W2072963128 hasAuthorship W2072963128A5054764500 @default.
• W2072963128 hasAuthorship W2072963128A5059405540 @default.
• W2072963128 hasAuthorship W2072963128A5067196342 @default.
• W2072963128 hasBestOaLocation W20729631281 @default.
• W2072963128 hasConcept C126322002 @default.
• W2072963128 hasConcept C141071460 @default.
• W2072963128 hasConcept C164705383 @default.
• W2072963128 hasConcept C2776820930 @default.
• W2072963128 hasConcept C2777090595 @default.
• W2072963128 hasConcept C2778881276 @default.
• W2072963128 hasConcept C2779750884 @default.
• W2072963128 hasConcept C2780069944 @default.
• W2072963128 hasConcept C3017915907 @default.
• W2072963128 hasConcept C42219234 @default.
• W2072963128 hasConcept C71924100 @default.
• W2072963128 hasConceptScore W2072963128C126322002 @default.
• W2072963128 hasConceptScore W2072963128C141071460 @default.
• W2072963128 hasConceptScore W2072963128C164705383 @default.
• W2072963128 hasConceptScore W2072963128C2776820930 @default.
• W2072963128 hasConceptScore W2072963128C2777090595 @default.
• W2072963128 hasConceptScore W2072963128C2778881276 @default.
• W2072963128 hasConceptScore W2072963128C2779750884 @default.
• W2072963128 hasConceptScore W2072963128C2780069944 @default.
• W2072963128 hasConceptScore W2072963128C3017915907 @default.
• W2072963128 hasConceptScore W2072963128C42219234 @default.
• W2072963128 hasConceptScore W2072963128C71924100 @default.
• W2072963128 hasIssue "6" @default.
• W2072963128 hasLocation W20729631281 @default.
• W2072963128 hasOpenAccess W2072963128 @default.
• W2072963128 hasPrimaryLocation W20729631281 @default.
• W2072963128 hasRelatedWork W2028751651 @default.
• W2072963128 hasRelatedWork W2077828710 @default.
• W2072963128 hasRelatedWork W2116711182 @default.
• W2072963128 hasRelatedWork W2149881929 @default.
• W2072963128 hasRelatedWork W2356234050 @default.
• W2072963128 hasRelatedWork W2389895053 @default.
• W2072963128 hasRelatedWork W2803154976 @default.
• W2072963128 hasRelatedWork W3193547074 @default.
• W2072963128 hasRelatedWork W4282045743 @default.
• W2072963128 hasRelatedWork W4380150359 @default.
• W2072963128 hasVolume "17" @default.
• W2072963128 isParatext "false" @default.
• W2072963128 isRetracted "false" @default.
• W2072963128 magId "2072963128" @default.
• W2072963128 workType "article" @default.