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• W2072967941 abstract "Despite the large number of studies on the phenomenon of imposex, the mechanism underlying the abnormal growth of male sexual characters onto females in numerous gastropod species is yet to be fully elucidated. Although several hypotheses have been raised over the years, a convincing body of evidence indicates that tributyltin-induced imposex involves the abnormal modulation of the retinoid X receptor (RXR). Here, we investigate the RXR gene transcription at different timings and tissues upon exposure to environmentally relevant concentrations of tributyltin (TBT) (100 ng Sn/L TBT) in both genders of the imposex susceptible gastropod Nucella lapillus. RXR gene transcription was determined at two time-points (i.e., before and after imposex initiation) by quantitative Real Time PCR in potential target tissues: the central nervous system (CNS), penis/penis forming area (PFA), gonads and digestive gland. TBT-exposure altered transcription of RXR gene in a tissue and sex specific manner. In the CNS, a significant down-regulation was observed in females both before and after imposex initiation (P ≤ 0.01 and P ≤ 0.05, respectively). A similar trend was observed in male CNS at the first time-point, although differences between control and the TBT-exposed group were just above significance (P = 0.059). The penis/PFA showed no differences in transcription of RXR gene between control and TBT exposed female snails before imposex induction, or before and after imposex initiation for males. However, male penis showed higher transcription of RXR gene in comparison to the PFA of females. After imposex has been induced, a significant (P ≤ 0.001) increase in transcription of RXR gene was observed in penis of females with vas deference sequence index (VDS) levels of 3–4 in comparison with the PFA of both control and imposex females with VDS 1–2. At advanced stages of imposex, females displayed RXR transcription patterns in penis identical to those of males, which points to a functional role of RXR in the penis of both genders. In the other tissues, gonads and digestive gland, RXR gene transcription was not affected by TBT, at any of the analysed time-points. These patterns of RXR gene transcription upon TBT exposure highlight the pivotal involvement of the CNS in the mechanism of imposex induction. We integrate the results in a conceptual model, and discuss the central role of RXR and the retinoic acid signalling pathways in imposex and male genitalia formation in gastropods." @default.
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• W2072967941 date "2011-01-01" @default.
• W2072967941 modified "2023-10-15" @default.
• W2072967941 title "Tributyltin-induced imposex in marine gastropods involves tissue-specific modulation of the retinoid X receptor" @default.
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• W2072967941 doi "https://doi.org/10.1016/j.aquatox.2010.09.022" @default.
• W2072967941 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21036407" @default.
• W2072967941 hasPublicationYear "2011" @default.
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