Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072968045> ?p ?o ?g. }
- W2072968045 endingPage "279" @default.
- W2072968045 startingPage "272" @default.
- W2072968045 abstract "Leptin treatment during lactation programmes for leptin resistance at adulthood, evidenced by hyperleptinaemia, hyperphagia and overweight. Since leptin is known to affect stress response, emotional behaviour and memory/learning performance, the objective of the present study was to evaluate whether neonatal hyperleptinaemia programmes anxiety-like and novelty-seeking behaviours as well as memory/learning in adult male rats. During the first 10 days of lactation (from PN1 to PN10), pups were s.c. injected once per day with either 50 microL of saline (SAL) or murine leptin (LEP - 8 microg/100 g of body mass, saline diluted). Serum leptin was assessed at PN10 and at PN150. Two separate experiments were carried out: 1) experiment one: at PN137, 29 SAL and 30 LEP rats were tested in the elevated plus-maze (EPM) and, at PN142, their behaviour was assessed in the hole board (HB) arena; 2) experiment two: at PN140, a different group of rats consisting of 53 SAL and 56 LEP animals were tested in the radial arm water maze (RAWM). Serum leptin concentration was higher in the LEP group at PN10 and at PN150. LEP animals spent significantly less time in the open arms of the EPM. Furthermore, the number of nose-pokes in the HB arena was higher in LEP rats. There were no differences between groups regarding latency to find the hidden platform in the RAWM. Our results suggests that a central mechanism of leptin resistance at adulthood, caused by neonatal hyperleptinaemia, is associated with an increased level of anxiety and also that it intensifies novelty seeking-behaviour." @default.
- W2072968045 created "2016-06-24" @default.
- W2072968045 creator A5025542643 @default.
- W2072968045 creator A5030337968 @default.
- W2072968045 creator A5052318027 @default.
- W2072968045 creator A5063019973 @default.
- W2072968045 creator A5072420490 @default.
- W2072968045 creator A5078229393 @default.
- W2072968045 creator A5082889700 @default.
- W2072968045 creator A5089513094 @default.
- W2072968045 date "2009-02-01" @default.
- W2072968045 modified "2023-10-10" @default.
- W2072968045 title "Neonatal hyperleptinaemia programmes anxiety-like and novelty seeking behaviours but not memory/learning in adult rats" @default.
- W2072968045 cites W140893707 @default.
- W2072968045 cites W1486463812 @default.
- W2072968045 cites W1541058978 @default.
- W2072968045 cites W1557193254 @default.
- W2072968045 cites W1559989352 @default.
- W2072968045 cites W1963558079 @default.
- W2072968045 cites W1967284402 @default.
- W2072968045 cites W1970687175 @default.
- W2072968045 cites W1986511921 @default.
- W2072968045 cites W1990694352 @default.
- W2072968045 cites W1990728215 @default.
- W2072968045 cites W1991981308 @default.
- W2072968045 cites W1993010689 @default.
- W2072968045 cites W2001585610 @default.
- W2072968045 cites W2004494896 @default.
- W2072968045 cites W2004820639 @default.
- W2072968045 cites W2005932233 @default.
- W2072968045 cites W2006287021 @default.
- W2072968045 cites W2007303473 @default.
- W2072968045 cites W2007675951 @default.
- W2072968045 cites W2007711534 @default.
- W2072968045 cites W2011482144 @default.
- W2072968045 cites W2012958393 @default.
- W2072968045 cites W2013668274 @default.
- W2072968045 cites W2018627820 @default.
- W2072968045 cites W2019138417 @default.
- W2072968045 cites W2023004197 @default.
- W2072968045 cites W2023254725 @default.
- W2072968045 cites W2024590659 @default.
- W2072968045 cites W2025846514 @default.
- W2072968045 cites W2027306026 @default.
- W2072968045 cites W2028291191 @default.
- W2072968045 cites W2029511053 @default.
- W2072968045 cites W2035283624 @default.
- W2072968045 cites W2037912513 @default.
- W2072968045 cites W2041561931 @default.
- W2072968045 cites W2043476202 @default.
- W2072968045 cites W2047867886 @default.
- W2072968045 cites W2048289776 @default.
- W2072968045 cites W2048636267 @default.
- W2072968045 cites W2048920034 @default.
- W2072968045 cites W2050251142 @default.
- W2072968045 cites W2055875395 @default.
- W2072968045 cites W2055950600 @default.
- W2072968045 cites W2061132963 @default.
- W2072968045 cites W2067487342 @default.
- W2072968045 cites W2071433424 @default.
- W2072968045 cites W2075019242 @default.
- W2072968045 cites W2079714688 @default.
- W2072968045 cites W2080324769 @default.
- W2072968045 cites W2081060958 @default.
- W2072968045 cites W2081965908 @default.
- W2072968045 cites W2082571287 @default.
- W2072968045 cites W2085245933 @default.
- W2072968045 cites W2090859936 @default.
- W2072968045 cites W2091643921 @default.
- W2072968045 cites W2095036452 @default.
- W2072968045 cites W2095428251 @default.
- W2072968045 cites W2096308730 @default.
- W2072968045 cites W2101826413 @default.
- W2072968045 cites W2109193958 @default.
- W2072968045 cites W2112583577 @default.
- W2072968045 cites W2116890198 @default.
- W2072968045 cites W2120023895 @default.
- W2072968045 cites W2121859528 @default.
- W2072968045 cites W2123717940 @default.
- W2072968045 cites W2141041835 @default.
- W2072968045 cites W2149734487 @default.
- W2072968045 cites W2149864803 @default.
- W2072968045 cites W2162060216 @default.
- W2072968045 cites W2163358562 @default.
- W2072968045 cites W2166284944 @default.
- W2072968045 cites W2168101730 @default.
- W2072968045 cites W2170798966 @default.
- W2072968045 cites W2172157844 @default.
- W2072968045 cites W2411921815 @default.
- W2072968045 cites W2462826688 @default.
- W2072968045 cites W4212849655 @default.
- W2072968045 cites W4236226181 @default.
- W2072968045 cites W4237969614 @default.
- W2072968045 cites W4244754748 @default.
- W2072968045 cites W4246919294 @default.
- W2072968045 cites W4253317366 @default.
- W2072968045 cites W4255304519 @default.
- W2072968045 cites W4293247451 @default.