FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072972015> ?p ?o ?g. }

• W2072972015 endingPage "179" @default.
• W2072972015 startingPage "169" @default.
• W2072972015 abstract "The metabolism of fluvoxamine to fluvoxamino acid is known to involve a two-step oxidation process via an alcohol intermediate, fluvoxamino alcohol. The present study was carried out to identify the cytochrome P450 (CYP) enzyme(s) involved in the metabolism of fluvoxamine to fluvoxamino alcohol using human liver microsomes and cDNA-expressed human CYP enzymes. The mean Km and Vmax values for the formation of fluvoxamino alcohol from fluvoxamine in human liver microsomes were 76.3 µM and 37.5 pmol min–1 mg–1 protein, respectively. The formation of fluvoxamino alcohol from fluvoxamine in pooled human liver microsomes was significantly inhibited by quinidine, a relatively specific CYP2D6 inhibitor, with a Ki value of 2.2 µM, whereas other several relatively specific CYP inhibitors did not inhibit the formation of fluvoxamino alcohol. In addition, only CYP2D6 of several cDNA-expressed human CYP enzymes examined showed substantial activity for the formation of fluvoxamino alcohol. Furthermore, the formation of fluvoxamino acid from fluvoxamino alcohol is potently inhibited by 4-methylpyrazole in human liver cytosol. These data suggest that CYP2D6 is the only enzyme predominantly responsible for the first-step oxidation of fluvoxamine to fluvoxamino alcohol, and alcohol dehydrogenase is involved in the second-step oxidation of fluvoxamino alcohol to the corresponding carbolic acid." @default.
• W2072972015 created "2016-06-24" @default.
• W2072972015 creator A5056194022 @default.
• W2072972015 creator A5086680208 @default.
• W2072972015 date "2007-02-01" @default.
• W2072972015 modified "2023-09-27" @default.
• W2072972015 title "Identification of human cytochrome P450 enzymes involved in the major metabolic pathway of fluvoxamine" @default.
• W2072972015 cites W1971939226 @default.
• W2072972015 cites W1984318995 @default.
• W2072972015 cites W1987889187 @default.
• W2072972015 cites W1990912030 @default.
• W2072972015 cites W1995862457 @default.
• W2072972015 cites W2001781507 @default.
• W2072972015 cites W2007983159 @default.
• W2072972015 cites W2008825099 @default.
• W2072972015 cites W2023116190 @default.
• W2072972015 cites W2023580320 @default.
• W2072972015 cites W2030995672 @default.
• W2072972015 cites W2032884131 @default.
• W2072972015 cites W2034821383 @default.
• W2072972015 cites W2039848755 @default.
• W2072972015 cites W2045654730 @default.
• W2072972015 cites W2046107045 @default.
• W2072972015 cites W2054377010 @default.
• W2072972015 cites W2060473370 @default.
• W2072972015 cites W2085978521 @default.
• W2072972015 cites W2087526401 @default.
• W2072972015 cites W2090628258 @default.
• W2072972015 cites W2092829315 @default.
• W2072972015 cites W2094440982 @default.
• W2072972015 cites W2315009583 @default.
• W2072972015 doi "https://doi.org/10.1080/00498250600718464" @default.
• W2072972015 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17484519" @default.
• W2072972015 hasPublicationYear "2007" @default.
• W2072972015 type Work @default.
• W2072972015 sameAs 2072972015 @default.
• W2072972015 citedByCount "18" @default.
• W2072972015 countsByYear W20729720152012 @default.
• W2072972015 countsByYear W20729720152013 @default.
• W2072972015 countsByYear W20729720152014 @default.
• W2072972015 countsByYear W20729720152015 @default.
• W2072972015 countsByYear W20729720152016 @default.
• W2072972015 countsByYear W20729720152017 @default.
• W2072972015 countsByYear W20729720152018 @default.
• W2072972015 countsByYear W20729720152019 @default.
• W2072972015 countsByYear W20729720152021 @default.
• W2072972015 countsByYear W20729720152022 @default.
• W2072972015 crossrefType "journal-article" @default.
• W2072972015 hasAuthorship W2072972015A5056194022 @default.
• W2072972015 hasAuthorship W2072972015A5086680208 @default.
• W2072972015 hasConcept C170493617 @default.
• W2072972015 hasConcept C181199279 @default.
• W2072972015 hasConcept C185592680 @default.
• W2072972015 hasConcept C2775864247 @default.
• W2072972015 hasConcept C2776134451 @default.
• W2072972015 hasConcept C2777344606 @default.
• W2072972015 hasConcept C2779910183 @default.
• W2072972015 hasConcept C2780161600 @default.
• W2072972015 hasConcept C2781066024 @default.
• W2072972015 hasConcept C33664856 @default.
• W2072972015 hasConcept C526171541 @default.
• W2072972015 hasConcept C55493867 @default.
• W2072972015 hasConcept C62231903 @default.
• W2072972015 hasConcept C86803240 @default.
• W2072972015 hasConcept C87644729 @default.
• W2072972015 hasConcept C98274493 @default.
• W2072972015 hasConceptScore W2072972015C170493617 @default.
• W2072972015 hasConceptScore W2072972015C181199279 @default.
• W2072972015 hasConceptScore W2072972015C185592680 @default.
• W2072972015 hasConceptScore W2072972015C2775864247 @default.
• W2072972015 hasConceptScore W2072972015C2776134451 @default.
• W2072972015 hasConceptScore W2072972015C2777344606 @default.
• W2072972015 hasConceptScore W2072972015C2779910183 @default.
• W2072972015 hasConceptScore W2072972015C2780161600 @default.
• W2072972015 hasConceptScore W2072972015C2781066024 @default.
• W2072972015 hasConceptScore W2072972015C33664856 @default.
• W2072972015 hasConceptScore W2072972015C526171541 @default.
• W2072972015 hasConceptScore W2072972015C55493867 @default.
• W2072972015 hasConceptScore W2072972015C62231903 @default.
• W2072972015 hasConceptScore W2072972015C86803240 @default.
• W2072972015 hasConceptScore W2072972015C87644729 @default.
• W2072972015 hasConceptScore W2072972015C98274493 @default.
• W2072972015 hasIssue "2" @default.
• W2072972015 hasLocation W20729720151 @default.
• W2072972015 hasLocation W20729720152 @default.
• W2072972015 hasOpenAccess W2072972015 @default.
• W2072972015 hasPrimaryLocation W20729720151 @default.
• W2072972015 hasRelatedWork W172509129 @default.
• W2072972015 hasRelatedWork W1976349950 @default.
• W2072972015 hasRelatedWork W1977911727 @default.
• W2072972015 hasRelatedWork W1980576851 @default.
• W2072972015 hasRelatedWork W2008445083 @default.
• W2072972015 hasRelatedWork W2042823474 @default.
• W2072972015 hasRelatedWork W2072972015 @default.
• W2072972015 hasRelatedWork W208714787 @default.
• W2072972015 hasRelatedWork W2095594987 @default.
• W2072972015 hasRelatedWork W2245636290 @default.
• W2072972015 hasVolume "37" @default.

• next