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- W2072972805 abstract "Induced pluripotent stem cells (iPSCs) hold great promise for autologous cell therapies, but significant roadblocks remain to translating iPSCs to the bedside. For example, concerns about the presumed autologous transplantation potential of iPSCs have been raised by a recent paper demonstrating that iPSC-derived teratomas were rejected by syngeneic hosts. Additionally, the reprogramming process can alter genomic and epigenomic states, so a key goal at this point is to determine the clinical relevance of these changes and minimize those that prove to be deleterious. Finally, thus far few studies have examined the efficacy and tumorigenicity of iPSCs in clinically relevant transplantation scenarios, an essential requirement for the FDA. We discuss potential solutions to these hurdles to provide a roadmap for iPSCs to jump the dish and become useful therapies." @default.
- W2072972805 created "2016-06-24" @default.
- W2072972805 creator A5013540086 @default.
- W2072972805 creator A5079670982 @default.
- W2072972805 date "2011-08-01" @default.
- W2072972805 modified "2023-10-14" @default.
- W2072972805 title "Inducing iPSCs to Escape the Dish" @default.
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- W2072972805 doi "https://doi.org/10.1016/j.stem.2011.07.006" @default.
- W2072972805 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3500137" @default.
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- W2072972805 hasPublicationYear "2011" @default.
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