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- W2072979824 abstract "The effect of phenoxybenzamine added in vitro to isolated rat liver mitochondria was investigated. Respiration was measured polarographically with either glutamate and malate or succinate as substrate in the presence of rotenone. Phenoxybenzamine inhibited the ADP-deficient (State 4), the ADP-activated (State 3), and the uncoupled (2,4-dinitrophenol, 40 μm) respiration with all substrates used. The inhibitory action of phenoxybenzamine was dependent on the amount of mitochondrial protein present in the reaction medium. The higher the mitochondrial concentration, the higher the concentration of phenoxybenzamine required for inhibition. Serum albumin up to 1.4 mg/ml did not alter the effect of phenoxybenzamine. The inhibition of respiration was not competitive with succinate." @default.
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- W2072979824 date "1971-10-01" @default.
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- W2072979824 title "Effect of phenoxybenzamine on the respiration of isolated rat liver mitochondria" @default.
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- W2072979824 doi "https://doi.org/10.1016/0006-2944(71)90043-3" @default.
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