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• W2072994579 startingPage "3691" @default.
• W2072994579 abstract "The first steps of transcription initiation include binding of RNA polymerase to a promoter to form an inactive, unstable, closed complex (described by an equilibrium constant, K B ) and isomerization of the closed complex to an active, stable, open complex (described by a forward rate constant, k f ). λ cI protein activates the P RM promoter by specifically increasing k f . A positive control mutant, cI-pc2, is defective for activation because it fails to raise k f . An Arg to His change in the σ 70 subunit of RNA polymerase was previously obtained as an allele-specific suppressor of cI-pc2 . To elucidate how the mutant polymerase restores the activation function of the mutant activator, abortive initiation assays were performed, using purified cI proteins and RNA polymerase holoenzymes. The change in σ does not significantly alter K B or k f in the absence of cI protein. As expected, cI-pc2 activates the mutant polymerase in the same way that wild-type cI activates the wild-type polymerase, by increasing k f . An unexpected and novel finding is that the wild-type activator stimulates the mutant polymerase, but not wild-type polymerase, by increasing K B ." @default.
• W2072994579 created "2016-06-24" @default.
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• W2072994579 date "1997-04-15" @default.
• W2072994579 modified "2023-09-27" @default.
• W2072994579 title "Changing the mechanism of transcriptional activation by phage λ repressor" @default.
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• W2072994579 doi "https://doi.org/10.1073/pnas.94.8.3691" @default.
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