Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073000557> ?p ?o ?g. }
- W2073000557 endingPage "271" @default.
- W2073000557 startingPage "261" @default.
- W2073000557 abstract "Disseminated tumor cells are present in many patients at diagnosis. At a time when the disseminated disease becomes prominent, patients have already been treated with many cycles of therapy to which their metastases were also exposed. These metastases have genetically evolved from primary tumors. Furthermore, their interaction with the tissue microenvironment plays an important role in all phases of disease development. These facts have only partially been taken into consideration when profiling anti-cancer compounds foreseen to treat patients with disseminated metastatic disease. In this perspective, we discuss the unique features of metastatic disease and review the model systems available for drug profiling. Based on an analysis of how compounds are profiled today in pre-clinical models of metastatic disease and what would be desirable and possible with the present know-how, we recommend a refined profiling process to validate drugs with potential to treat patients with overt metastatic disease." @default.
- W2073000557 created "2016-06-24" @default.
- W2073000557 creator A5011986659 @default.
- W2073000557 creator A5085220366 @default.
- W2073000557 date "2012-06-01" @default.
- W2073000557 modified "2023-09-26" @default.
- W2073000557 title "Metastatic disease: A drug discovery perspective" @default.
- W2073000557 cites W1229827077 @default.
- W2073000557 cites W1338787 @default.
- W2073000557 cites W1480357432 @default.
- W2073000557 cites W1506680628 @default.
- W2073000557 cites W1516603921 @default.
- W2073000557 cites W1518520618 @default.
- W2073000557 cites W1520425169 @default.
- W2073000557 cites W1579189600 @default.
- W2073000557 cites W1582847607 @default.
- W2073000557 cites W1642344961 @default.
- W2073000557 cites W1907241018 @default.
- W2073000557 cites W1964081206 @default.
- W2073000557 cites W1967293289 @default.
- W2073000557 cites W1967325169 @default.
- W2073000557 cites W1967600348 @default.
- W2073000557 cites W1971092719 @default.
- W2073000557 cites W1971801942 @default.
- W2073000557 cites W1971992633 @default.
- W2073000557 cites W1974740818 @default.
- W2073000557 cites W1975769848 @default.
- W2073000557 cites W1976992968 @default.
- W2073000557 cites W1978422731 @default.
- W2073000557 cites W1979901771 @default.
- W2073000557 cites W1980039397 @default.
- W2073000557 cites W1980497534 @default.
- W2073000557 cites W1982441587 @default.
- W2073000557 cites W1988698591 @default.
- W2073000557 cites W1993497779 @default.
- W2073000557 cites W1993544519 @default.
- W2073000557 cites W1993866387 @default.
- W2073000557 cites W2000200648 @default.
- W2073000557 cites W2000905326 @default.
- W2073000557 cites W2002250199 @default.
- W2073000557 cites W2003213153 @default.
- W2073000557 cites W2004403900 @default.
- W2073000557 cites W2004834404 @default.
- W2073000557 cites W2005334224 @default.
- W2073000557 cites W2005946855 @default.
- W2073000557 cites W2007040134 @default.
- W2073000557 cites W2007599495 @default.
- W2073000557 cites W2009927285 @default.
- W2073000557 cites W2010251891 @default.
- W2073000557 cites W2011666308 @default.
- W2073000557 cites W2012235549 @default.
- W2073000557 cites W2012247886 @default.
- W2073000557 cites W2014119944 @default.
- W2073000557 cites W2015032157 @default.
- W2073000557 cites W2018723375 @default.
- W2073000557 cites W2019097500 @default.
- W2073000557 cites W2020131167 @default.
- W2073000557 cites W2022283992 @default.
- W2073000557 cites W2023292535 @default.
- W2073000557 cites W2026105950 @default.
- W2073000557 cites W2026548544 @default.
- W2073000557 cites W2028063515 @default.
- W2073000557 cites W2028701135 @default.
- W2073000557 cites W2031599610 @default.
- W2073000557 cites W2032461554 @default.
- W2073000557 cites W2032982849 @default.
- W2073000557 cites W2034428193 @default.
- W2073000557 cites W2039725154 @default.
- W2073000557 cites W2041353769 @default.
- W2073000557 cites W2042210471 @default.
- W2073000557 cites W2046861065 @default.
- W2073000557 cites W2048497600 @default.
- W2073000557 cites W2049150145 @default.
- W2073000557 cites W2052420703 @default.
- W2073000557 cites W2052421497 @default.
- W2073000557 cites W2057359010 @default.
- W2073000557 cites W2058362959 @default.
- W2073000557 cites W2061275679 @default.
- W2073000557 cites W2062265555 @default.
- W2073000557 cites W2063140987 @default.
- W2073000557 cites W2066254965 @default.
- W2073000557 cites W2070831760 @default.
- W2073000557 cites W2071398310 @default.
- W2073000557 cites W2071848682 @default.
- W2073000557 cites W2072952115 @default.
- W2073000557 cites W2074469498 @default.
- W2073000557 cites W2079239846 @default.
- W2073000557 cites W2080264320 @default.
- W2073000557 cites W2080773973 @default.
- W2073000557 cites W2085136169 @default.
- W2073000557 cites W2089370460 @default.
- W2073000557 cites W2090629948 @default.
- W2073000557 cites W2091336659 @default.
- W2073000557 cites W2094454542 @default.
- W2073000557 cites W2096031499 @default.
- W2073000557 cites W2098900183 @default.
- W2073000557 cites W2099022883 @default.
- W2073000557 cites W2101037339 @default.