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• W2073000872 abstract "Whether odorants are transduced by only one or more than one second messenger has been a long-standing question in olfactory research. In a previous study we started to address this question mainly by using calcium imaging in the olfactory bulb. Here, we present direct evidence for our earlier conclusions using the calcium imaging technique in the mucosa slice. The above question can now unambiguously be answered. We show that some olfactory receptor neurons (ORNs) respond to stimulation with amino acids with an increase of the intracellular calcium concentration [Ca2+]i. In order to see whether or not these responses were mediated by the cAMP transduction pathway we applied forskolin or the membrane-permeant cAMP analogue pCPT-cAMP to the olfactory epithelium. The ensemble of ORNs that was activated by amino acids markedly differed from the ensemble of neurons activated by forskolin or pCPT-cAMP. Less than 6 % of the responding ORNs showed a response to both amino acids and the pharmacological agents activating the cAMP transduction pathway. We conclude that ORNs of Xenopus laevis tadpoles have both cAMP-dependent and cAMP-independent olfactory transduction pathways and that most amino acids are transduced in a cAMP-independent way." @default.
• W2073000872 created "2016-06-24" @default.
• W2073000872 creator A5027102339 @default.
• W2073000872 creator A5029411176 @default.
• W2073000872 date "2003-08-01" @default.
• W2073000872 modified "2023-10-02" @default.
• W2073000872 title "cAMP-independent olfactory transduction of amino acids in Xenopus laevis tadpoles" @default.
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• W2073000872 doi "https://doi.org/10.1111/j.1469-7793.2003.00115.x" @default.
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