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- W2073001178 abstract "Guidance molecules steer growth cones to their targets by attracting or repelling them. Turning in a new direction requires remodeling of the growth cone and bending of the axon. This depends upon reorganization of actin filaments and microtubules, which are the primary cytoskeletal components of growth cones. This article discusses how these cytoskeletal components induce turning. The importance of each component as well as how interactions between them result in axon guidance is discussed. Current evidence shows that microtubules are influenced by both the organization and dynamics of actin filaments in the peripheral domain of growth cones. Cytoskeletal models for repulsive and attractive turning are presented. Molecular candidates that may link actin filaments with microtubules are suggested and potential signal transduction pathways that allow these cytoskeletal components to affect each other are discussed." @default.
- W2073001178 created "2016-06-24" @default.
- W2073001178 creator A5011646287 @default.
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- W2073001178 date "2003-10-29" @default.
- W2073001178 modified "2023-10-09" @default.
- W2073001178 title "How actin filaments and microtubules steer growth cones to their targets" @default.
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- W2073001178 doi "https://doi.org/10.1002/neu.10278" @default.
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