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- W2073003323 abstract "Selective delivery of antioxidants to the substantia nigra pars compacta (SNpc) during Parkinson's disease (PD) can potentially attenuate oxidative stress and as such increase survival of dopaminergic neurons. To this end, we developed a bone-marrow-derived macrophage (BMM) system to deliver catalase to PD-affected brain regions in an animal model of human disease. To preclude BMM-mediated enzyme degradation, catalase was packaged into a block ionomer complex with a cationic block copolymer, polyethyleneimine-poly(ethylene glycol) (PEI-PEG). The self-assembled catalase/PEI-PEG complexes, “nanozymes”, were ca. 60 to 100 nm in size, stable in pH and ionic strength, and retained antioxidant activities. Cytotoxicity was negligible over a range of physiologic nanozyme concentrations. Nanozyme particles were rapidly, 40−60 min, taken up by BMM, retained catalytic activity, and released in active form for greater than 24 h. In contrast, “naked” catalase was rapidly degraded. The released enzyme decomposed microglial hydrogen peroxide following nitrated alpha-synuclein or tumor necrosis factor alpha activation. Following adoptive transfer of nanozyme-loaded BMM to 1-methyl 4-phenyl 1,2,3,6-tetrahydropyridine-intoxicated mice, ca. 0.6% of the injected dose were found in brain. We conclude that cell-mediated delivery of nanozymes can reduce oxidative stress in laboratory and animal models of PD." @default.
- W2073003323 created "2016-06-24" @default.
- W2073003323 creator A5006955096 @default.
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- W2073003323 creator A5060883440 @default.
- W2073003323 creator A5074045641 @default.
- W2073003323 creator A5086463632 @default.
- W2073003323 date "2007-08-31" @default.
- W2073003323 modified "2023-10-06" @default.
- W2073003323 title "A Macrophage−Nanozyme Delivery System for Parkinson's Disease" @default.
- W2073003323 cites W11579461 @default.
- W2073003323 cites W1493537648 @default.
- W2073003323 cites W1608305635 @default.
- W2073003323 cites W17131581 @default.
- W2073003323 cites W1962589009 @default.
- W2073003323 cites W1969911722 @default.
- W2073003323 cites W1970340961 @default.
- W2073003323 cites W1971701992 @default.
- W2073003323 cites W1973316675 @default.
- W2073003323 cites W1973385841 @default.
- W2073003323 cites W1973774460 @default.
- W2073003323 cites W1973891258 @default.
- W2073003323 cites W1974924674 @default.
- W2073003323 cites W1975308788 @default.
- W2073003323 cites W1975331070 @default.
- W2073003323 cites W1976390944 @default.
- W2073003323 cites W1977246374 @default.
- W2073003323 cites W1978483334 @default.
- W2073003323 cites W1985631236 @default.
- W2073003323 cites W1987274486 @default.
- W2073003323 cites W1988771401 @default.
- W2073003323 cites W1988867798 @default.
- W2073003323 cites W1992182695 @default.
- W2073003323 cites W1992689843 @default.
- W2073003323 cites W1992998779 @default.
- W2073003323 cites W1993441114 @default.
- W2073003323 cites W1997395033 @default.
- W2073003323 cites W1997781505 @default.
- W2073003323 cites W1999309679 @default.
- W2073003323 cites W2011123334 @default.
- W2073003323 cites W2014370099 @default.
- W2073003323 cites W2014676363 @default.
- W2073003323 cites W2015928561 @default.
- W2073003323 cites W2016336099 @default.
- W2073003323 cites W2022047142 @default.
- W2073003323 cites W2024420787 @default.
- W2073003323 cites W2029749273 @default.
- W2073003323 cites W2033937869 @default.
- W2073003323 cites W2039963993 @default.
- W2073003323 cites W2040700904 @default.
- W2073003323 cites W2041221762 @default.
- W2073003323 cites W2041229020 @default.
- W2073003323 cites W2042630261 @default.
- W2073003323 cites W2044352000 @default.
- W2073003323 cites W2045230140 @default.
- W2073003323 cites W2045573038 @default.
- W2073003323 cites W2045992463 @default.
- W2073003323 cites W2048137214 @default.
- W2073003323 cites W2051609383 @default.
- W2073003323 cites W2053180614 @default.
- W2073003323 cites W2056735686 @default.
- W2073003323 cites W2060042438 @default.
- W2073003323 cites W2061154270 @default.
- W2073003323 cites W2062927833 @default.
- W2073003323 cites W2067105161 @default.
- W2073003323 cites W2067867285 @default.
- W2073003323 cites W2071111614 @default.
- W2073003323 cites W2074254849 @default.
- W2073003323 cites W2080499279 @default.
- W2073003323 cites W2082105104 @default.
- W2073003323 cites W2086296428 @default.
- W2073003323 cites W2090740833 @default.
- W2073003323 cites W2097358583 @default.
- W2073003323 cites W2098160583 @default.
- W2073003323 cites W2103738800 @default.
- W2073003323 cites W2108060249 @default.
- W2073003323 cites W2123568006 @default.
- W2073003323 cites W2128631317 @default.
- W2073003323 cites W2133172062 @default.
- W2073003323 cites W2140333493 @default.
- W2073003323 cites W2140595333 @default.
- W2073003323 cites W2144102286 @default.
- W2073003323 cites W2148726772 @default.
- W2073003323 cites W2148820585 @default.
- W2073003323 cites W2151760476 @default.
- W2073003323 cites W2167590613 @default.
- W2073003323 cites W2171047055 @default.
- W2073003323 cites W217497694 @default.
- W2073003323 cites W2188400884 @default.
- W2073003323 cites W2301404923 @default.
- W2073003323 cites W2340746171 @default.
- W2073003323 cites W2374159384 @default.
- W2073003323 cites W2411005205 @default.
- W2073003323 cites W2414791078 @default.
- W2073003323 cites W25899008 @default.
- W2073003323 cites W26133678 @default.