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• W2073005726 abstract "Mechanisms of human Vγ2Vδ2 T cell-mediated tumor immunity have yet to be fully elucidated.At least some tumor cell recognition is mediated by NKG2D-MICA interactions. Herein, by using MTT assay and PI-BrdU co-staining and Western-blot, we show that these Vγ2Vδ2 T cells can limit the proliferation of ovarian tumor cells by down regulation of apoptosis and cell cycle related molecules in tumor cells. Cell-to-cell contact is critical. γδ T cell-resistant, but not susceptible ovarian tumor cells escape γδ T cell-mediated immune recognition by up-regulating pErk1/2, thereby decreasing surface MICA levels. Erk1/2 inhibitor pretreatment or incubation prevents this MICA decrease, while up-regulating key cell cycle related molecules such as CDK2, CDK4 and Cyclin D1, as well as apoptosis related molecules making resistant tumor cells now vulnerable to γδ T cell-mediated lysis.These findings demonstrate novel effects of γδT cells on ovarian tumor cells." @default.
• W2073005726 created "2016-06-24" @default.
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• W2073005726 date "2011-09-14" @default.
• W2073005726 modified "2023-10-14" @default.
• W2073005726 title "Human Ovarian Tumor Cells Escape γδ T Cell Recognition Partly by Down Regulating Surface Expression of MICA and Limiting Cell Cycle Related Molecules" @default.
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• W2073005726 doi "https://doi.org/10.1371/journal.pone.0023348" @default.
• W2073005726 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3173356" @default.
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• W2073005726 hasPublicationYear "2011" @default.
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