FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073007459> ?p ?o ?g. }

• W2073007459 endingPage "495" @default.
• W2073007459 startingPage "490" @default.
• W2073007459 abstract "Objective: The aim of this study was to investigate the ability of topiramate (TPM) to prevent neural injury in a rabbit model of subarachnoid hemorrhage (SAH). The effect of TPM on cerebral vasospasm was also evaluated. Methods: Fifty-three New Zealand white rabbits were allocated into three groups randomly. SAH was induced by injecting autologous blood into the cisterna magna. The treatment groups were as follows: (1) sham operated (no SAH (n=18); (2) SAH only (n=17); (3) SAH + TPM (n=18). Hippocampal sections were evaluated for neural tissue degeneration, using the previously described neural degeneration scoring system. The ApopTag peroxidase in situ apoptosis detection kit (Serologicals Corp., former Intergen) was used to assess apoptosis in the hippocampal sections and the effect of TPM on the apoptotic response. Basilar artery lumen areas and arterial wall thickness were also measured in all groups. Results: There was a statistically significant difference between the mean degeneration scores of the control and SAH only groups (p<0.05). The level of neural degeneration in TPM treated group was significantly lower compared with SAH only group (p<0.05), but not significantly higher than the control group (p>0.05). There were no statistically significant differences between arterial cross-sectional area and arterial wall thickness measurements of the SAH group and SAH + TPM group. Conclusion: These findings demonstrate that TPM has marked neuroprotective effect in an experimental model of SAH in rabbits. This observation may have clinical implications suggesting that this antiepileptic drug could be used as a possible neuroprotective agent in patients without major adverse effects." @default.
• W2073007459 created "2016-06-24" @default.
• W2073007459 creator A5011855482 @default.
• W2073007459 creator A5033337814 @default.
• W2073007459 creator A5035165811 @default.
• W2073007459 creator A5043320072 @default.
• W2073007459 creator A5053396624 @default.
• W2073007459 creator A5055649154 @default.
• W2073007459 creator A5066036043 @default.
• W2073007459 creator A5080965934 @default.
• W2073007459 date "2009-06-01" @default.
• W2073007459 modified "2023-10-09" @default.
• W2073007459 title "Topiramate attenuates hippocampal injury after experimental subarachnoid hemorrhage in rabbits" @default.
• W2073007459 cites W1964308916 @default.
• W2073007459 cites W1974311184 @default.
• W2073007459 cites W1978935992 @default.
• W2073007459 cites W2008421055 @default.
• W2073007459 cites W2016432309 @default.
• W2073007459 cites W2023520406 @default.
• W2073007459 cites W2045180954 @default.
• W2073007459 cites W2051838624 @default.
• W2073007459 cites W2067206196 @default.
• W2073007459 cites W2075000113 @default.
• W2073007459 cites W2076870712 @default.
• W2073007459 cites W2080558481 @default.
• W2073007459 cites W2082141491 @default.
• W2073007459 cites W2082205679 @default.
• W2073007459 cites W2088293934 @default.
• W2073007459 cites W2090170205 @default.
• W2073007459 cites W2106773303 @default.
• W2073007459 cites W2137911312 @default.
• W2073007459 cites W2141637053 @default.
• W2073007459 cites W2146972564 @default.
• W2073007459 cites W2157638257 @default.
• W2073007459 cites W4210962255 @default.
• W2073007459 doi "https://doi.org/10.1179/016164108x339369" @default.
• W2073007459 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19500452" @default.
• W2073007459 hasPublicationYear "2009" @default.
• W2073007459 type Work @default.
• W2073007459 sameAs 2073007459 @default.
• W2073007459 citedByCount "9" @default.
• W2073007459 countsByYear W20730074592012 @default.
• W2073007459 countsByYear W20730074592013 @default.
• W2073007459 countsByYear W20730074592014 @default.
• W2073007459 countsByYear W20730074592015 @default.
• W2073007459 countsByYear W20730074592016 @default.
• W2073007459 countsByYear W20730074592018 @default.
• W2073007459 countsByYear W20730074592021 @default.
• W2073007459 crossrefType "journal-article" @default.
• W2073007459 hasAuthorship W2073007459A5011855482 @default.
• W2073007459 hasAuthorship W2073007459A5033337814 @default.
• W2073007459 hasAuthorship W2073007459A5035165811 @default.
• W2073007459 hasAuthorship W2073007459A5043320072 @default.
• W2073007459 hasAuthorship W2073007459A5053396624 @default.
• W2073007459 hasAuthorship W2073007459A5055649154 @default.
• W2073007459 hasAuthorship W2073007459A5066036043 @default.
• W2073007459 hasAuthorship W2073007459A5080965934 @default.
• W2073007459 hasConcept C118552586 @default.
• W2073007459 hasConcept C126322002 @default.
• W2073007459 hasConcept C131631996 @default.
• W2073007459 hasConcept C141071460 @default.
• W2073007459 hasConcept C148762608 @default.
• W2073007459 hasConcept C25498285 @default.
• W2073007459 hasConcept C2776820941 @default.
• W2073007459 hasConcept C2777683783 @default.
• W2073007459 hasConcept C2777736543 @default.
• W2073007459 hasConcept C2778186239 @default.
• W2073007459 hasConcept C2778200158 @default.
• W2073007459 hasConcept C2778506911 @default.
• W2073007459 hasConcept C2779651940 @default.
• W2073007459 hasConcept C2781012200 @default.
• W2073007459 hasConcept C42219234 @default.
• W2073007459 hasConcept C71924100 @default.
• W2073007459 hasConceptScore W2073007459C118552586 @default.
• W2073007459 hasConceptScore W2073007459C126322002 @default.
• W2073007459 hasConceptScore W2073007459C131631996 @default.
• W2073007459 hasConceptScore W2073007459C141071460 @default.
• W2073007459 hasConceptScore W2073007459C148762608 @default.
• W2073007459 hasConceptScore W2073007459C25498285 @default.
• W2073007459 hasConceptScore W2073007459C2776820941 @default.
• W2073007459 hasConceptScore W2073007459C2777683783 @default.
• W2073007459 hasConceptScore W2073007459C2777736543 @default.
• W2073007459 hasConceptScore W2073007459C2778186239 @default.
• W2073007459 hasConceptScore W2073007459C2778200158 @default.
• W2073007459 hasConceptScore W2073007459C2778506911 @default.
• W2073007459 hasConceptScore W2073007459C2779651940 @default.
• W2073007459 hasConceptScore W2073007459C2781012200 @default.
• W2073007459 hasConceptScore W2073007459C42219234 @default.
• W2073007459 hasConceptScore W2073007459C71924100 @default.
• W2073007459 hasIssue "5" @default.
• W2073007459 hasLocation W20730074591 @default.
• W2073007459 hasLocation W20730074592 @default.
• W2073007459 hasOpenAccess W2073007459 @default.
• W2073007459 hasPrimaryLocation W20730074591 @default.
• W2073007459 hasRelatedWork W1987118893 @default.
• W2073007459 hasRelatedWork W1988363703 @default.
• W2073007459 hasRelatedWork W2016261780 @default.
• W2073007459 hasRelatedWork W2018028464 @default.

• next