FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073010492> ?p ?o ?g. }

• W2073010492 endingPage "1321" @default.
• W2073010492 startingPage "1316" @default.
• W2073010492 abstract "Abstract Both hypermethylation of the tumor suppressor gene RASSF1A and activating mutations of the KRAS and/or BRAF gene have been reported in a variety of human cancers. To investigate these epigenetic and genetic alterations in endometrial carcinoma (EC), we examined their frequency in 4 uterine EC cell lines and in 75 sporadic primary ECs. Using methylation specific PCR, we found RASSF1A methylation in 25 of 75 (33.3%) ECs. RASSF1A methylation was significantly associated with microsatellite instability (MSI, p < 0.001) and also with hMLH1 methylation ( p < 0.001). KRAS mutations were detected in 14 of 75 (18.7%) ECs. BRAF mutations were identified in only 3 of 75 (4.0%) ECs and were not found in ECs with KRAS mutations or RASSF1A methylation. RASSF1A methylation was more frequent in KRAS mutation‐negative ECs than in KRAS mutation‐positive ECs (37.7% vs 14.3%), but this inverse correlation is not statistically significant ( p = 0.122). However, we observed that RASSF1A methylation was inversely correlated with KRAS and/or BRAF mutations ( p = 0.028) in MSI‐negative ECs, while this inverse correlation disappeared in MSI‐positive ECs. Furthermore, in MSI‐positive ECs, 2 cases of concomitant RASSF1A methylation and KRAS mutation were found. Taken together, these results provide strong evidence that, in EC tumorigenesis, RASSF1A promoter hypermethylation is as important as KRAS mutations in activating the RAS pathway. © 2006 Wiley‐Liss, Inc." @default.
• W2073010492 created "2016-06-24" @default.
• W2073010492 creator A5002066826 @default.
• W2073010492 creator A5022141835 @default.
• W2073010492 creator A5033108441 @default.
• W2073010492 creator A5046315628 @default.
• W2073010492 creator A5049209796 @default.
• W2073010492 creator A5054806149 @default.
• W2073010492 creator A5063691131 @default.
• W2073010492 creator A5068136594 @default.
• W2073010492 creator A5080823003 @default.
• W2073010492 creator A5084213338 @default.
• W2073010492 date "2006-04-17" @default.
• W2073010492 modified "2023-10-17" @default.
• W2073010492 title "<i>RASSF1A</i> hypermethylation and its inverse correlation with <i>BRAF</i> and/or <i>KRAS</i> mutations in MSI‐associated endometrial carcinoma" @default.
• W2073010492 cites W1504197144 @default.
• W2073010492 cites W1953337176 @default.
• W2073010492 cites W1971778334 @default.
• W2073010492 cites W1985035689 @default.
• W2073010492 cites W1992762415 @default.
• W2073010492 cites W1994465394 @default.
• W2073010492 cites W1995806028 @default.
• W2073010492 cites W2005805996 @default.
• W2073010492 cites W2032053235 @default.
• W2073010492 cites W2034066784 @default.
• W2073010492 cites W2046542611 @default.
• W2073010492 cites W2051000036 @default.
• W2073010492 cites W2052333525 @default.
• W2073010492 cites W2053246551 @default.
• W2073010492 cites W2064372625 @default.
• W2073010492 cites W2070401223 @default.
• W2073010492 cites W2077475263 @default.
• W2073010492 cites W2077894633 @default.
• W2073010492 cites W2081499490 @default.
• W2073010492 cites W2087457210 @default.
• W2073010492 cites W2087592146 @default.
• W2073010492 cites W2088232329 @default.
• W2073010492 cites W2090925814 @default.
• W2073010492 cites W2092641158 @default.
• W2073010492 cites W2105928180 @default.
• W2073010492 cites W2113459016 @default.
• W2073010492 cites W2115516953 @default.
• W2073010492 cites W2116602941 @default.
• W2073010492 cites W2118556263 @default.
• W2073010492 cites W2157728397 @default.
• W2073010492 cites W2158150128 @default.
• W2073010492 cites W2161526619 @default.
• W2073010492 cites W2163188200 @default.
• W2073010492 doi "https://doi.org/10.1002/ijc.21991" @default.
• W2073010492 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16619251" @default.
• W2073010492 hasPublicationYear "2006" @default.
• W2073010492 type Work @default.
• W2073010492 sameAs 2073010492 @default.
• W2073010492 citedByCount "32" @default.
• W2073010492 countsByYear W20730104922012 @default.
• W2073010492 countsByYear W20730104922013 @default.
• W2073010492 countsByYear W20730104922015 @default.
• W2073010492 countsByYear W20730104922016 @default.
• W2073010492 countsByYear W20730104922017 @default.
• W2073010492 countsByYear W20730104922022 @default.
• W2073010492 countsByYear W20730104922023 @default.
• W2073010492 crossrefType "journal-article" @default.
• W2073010492 hasAuthorship W2073010492A5002066826 @default.
• W2073010492 hasAuthorship W2073010492A5022141835 @default.
• W2073010492 hasAuthorship W2073010492A5033108441 @default.
• W2073010492 hasAuthorship W2073010492A5046315628 @default.
• W2073010492 hasAuthorship W2073010492A5049209796 @default.
• W2073010492 hasAuthorship W2073010492A5054806149 @default.
• W2073010492 hasAuthorship W2073010492A5063691131 @default.
• W2073010492 hasAuthorship W2073010492A5068136594 @default.
• W2073010492 hasAuthorship W2073010492A5080823003 @default.
• W2073010492 hasAuthorship W2073010492A5084213338 @default.
• W2073010492 hasBestOaLocation W20730104921 @default.
• W2073010492 hasConcept C104317684 @default.
• W2073010492 hasConcept C150194340 @default.
• W2073010492 hasConcept C153911025 @default.
• W2073010492 hasConcept C180754005 @default.
• W2073010492 hasConcept C190727270 @default.
• W2073010492 hasConcept C2779767149 @default.
• W2073010492 hasConcept C2781187634 @default.
• W2073010492 hasConcept C33288867 @default.
• W2073010492 hasConcept C41091548 @default.
• W2073010492 hasConcept C501734568 @default.
• W2073010492 hasConcept C502942594 @default.
• W2073010492 hasConcept C54355233 @default.
• W2073010492 hasConcept C555283112 @default.
• W2073010492 hasConcept C61320498 @default.
• W2073010492 hasConcept C86803240 @default.
• W2073010492 hasConceptScore W2073010492C104317684 @default.
• W2073010492 hasConceptScore W2073010492C150194340 @default.
• W2073010492 hasConceptScore W2073010492C153911025 @default.
• W2073010492 hasConceptScore W2073010492C180754005 @default.
• W2073010492 hasConceptScore W2073010492C190727270 @default.
• W2073010492 hasConceptScore W2073010492C2779767149 @default.
• W2073010492 hasConceptScore W2073010492C2781187634 @default.
• W2073010492 hasConceptScore W2073010492C33288867 @default.
• W2073010492 hasConceptScore W2073010492C41091548 @default.
• W2073010492 hasConceptScore W2073010492C501734568 @default.

• next