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• W2073012362 abstract "To study the effect of high-fat diets with varying contents of n − 3 and n − 6 fatty acids on the metabolism of essential fatty acids, the rat liver microsomal fatty acid desaturases were measured. The rats were fed for 3 weeks with diets high in linseed oil (18:3(n − 3)), sunflower seed oil (18:2(n − 6)) or fish oil (20:5(n − 3) and 22:6(n − 3)) (20%, w/w) using pellet fed rats as a reference. The Δ6-desaturase using 18:2(n − 6) or 18:3(n − 3) as substrates was stimulated 1.5–2.5-fold by linseed or sunflower seed oil, compared to the pellet reference. The Δ5-desaturase was stimulated 3.5-fold with linseed oil and 2.5-fold with sunflower seed oil, while the Δ9-desaturase was inhibited by all the high-fat diets. The Δ6-, 5- and 9-desaturase activities were in all cases considerably reduced with fish oil as compared to linseed and sunflower seed oil diets. With pellet fed rats the rates were highest for Δ9-desaturation and in decreasing order lower for Δ5-desaturation, Δ6-desaturation with 18:3 (n − 3) as substrate and finally Δ6-Desaturation with 18:2(n − 6) as substrate. The content of 20:4(n − 6) in liver phospholipids increased with the diets rich in 18:2(n − 6), and was reduced for the fish oil diet enriched in 20:5 and 22:6(n − 3) fatty acids. The amount of 20:5(n − 3) in phospholipids was as high with linseed oil diet as with the fish oil diet, while the 22:6(n − 3) content was only increased with the fish oil diet." @default.
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• W2073012362 date "1991-02-01" @default.
• W2073012362 modified "2023-09-26" @default.
• W2073012362 title "Effect of dietary n − 3 and n − 6 fatty acids on fatty acid desaturation in rat liver" @default.
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• W2073012362 doi "https://doi.org/10.1016/0005-2760(91)90299-w" @default.
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