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- W2073018502 abstract "Background To examine outcomes of neoadjuvant endocrine therapy in daily practice to inform decision making. Methods We retrospectively selected 204 patients who received neoadjuvant endocrine therapy with T2 (≥30 mm) or T3 tumors, examining subsequent breast-sparing surgery and long-term outcomes. Results Neoadjuvant endocrine therapy was administered for 7.3 months (median) and breast-sparing surgery was achievable in 53% of patients. Smaller initial tumor size and modified version of the Scarff–Bloom and Richardson grades 1 to 2 were associated with breast-sparing surgery. Disease progression during treatment was 6.9%; actuarial risk of local relapse was 3% at 5 years and 15% at 10 years. Five- and 10-year metastasis relapse-free survival was 78% and 63%, respectively. Grade 3, negative progesterone receptors, and absence or slow response to neoadjuvant therapy were associated prognostic factors. Conclusion These daily practice data provide important information about feasibility, efficacy, and long-term results of neoadjuvant endocrine therapy and can be used to inform patients for decision making between mastectomy and endocrine induction therapy." @default.
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- W2073018502 date "2014-11-01" @default.
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- W2073018502 title "Neoadjuvant endocrine treatment in breast cancer: analysis of daily practice in large cancer center to facilitate decision making" @default.
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- W2073018502 doi "https://doi.org/10.1016/j.amjsurg.2013.12.032" @default.
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