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- W2073019213 abstract "The compartmentation ofl-glutamate in the central nervous system has been extensively studied andl-glutamine is believed to be the precursor of the neuronal releasable pool of thel-glutamate. In order to localize the sites of uptake of bothl-glutamate andl-glutamine, autoradiography was used in tissue slices of adult rat cerebellum, where granule cells are considered to be glutamatergic. Incubation of the tissue with low concentrations of [3H]l-glutamate or [3H]l-glutamine produces in both cases a heavy labelling of the molecular layer. [3H]l-glutamate uptake seems to be essentially glial (Golgi epithelial cells and Bergmann fibres) while [3H]l-glutamine is more diffusely distributed over the molecular layer. Although no conclusions can be drawn on the nature ofl-glutamine uptake, these results are in agreement with the model which considersl-glutamate uptake by glial cells to be the inactivating process of glutamatergic synapses." @default.
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- W2073019213 date "1982-05-01" @default.
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- W2073019213 title "l-glutamate andl-glutamine uptake in adult rat cerebellum: An autoradiographic study" @default.
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- W2073019213 doi "https://doi.org/10.1016/0306-4522(82)91134-4" @default.
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