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- W2073026462 abstract "Cardiac restitution kinetics (RK) of action potential duration (APD) has been extensively linked to arrhythmia vulnerability yet because of technical limitations, RK has not been measured when diastolic intervals (DI) are altered by direct sympathetic nerve activity. We used a novel isolated, fully innervated perfused rabbit heart preparation and combined it with optical mapping to measure APD RK in the left ventricle (n=3). Sympathetic nerves were stimulated bilaterally at the thoracic outflow in the spinal cord at 5, 10 or 15 Hz until heart rate (HR) reached a maximum and APDs a minimum then nerve stimulation was stopped and HR allowed to recover while tracking beat-to-beat activation intervals (AI) and APDs. Hearts were then paced with the same pattern of AI vs. time with a computer generated pacing protocol. Once the maximum HR was reached, APDs continued to decrease, more so with sympathetic than with pacing. APD vs. DI curves for sympathetic nerve stimulation and epi-pacing exhibited different hysteresis loops, with markedly different positive and negative slopes despite identical changes in heart rate (see figure). In addition, the range of APDs changes vs. DI were smaller in pacing as compared to sympathetic stimulation (paired t-test, P < 0.05), exposing the effects of beta-adrenergic activation and cellular signaling processes on RK. Although their significance remains unclear, RK curves derived from physiological sympathetic activity of the autonomic nervous system are shown for the first time to differ from standard restitution curves derived from direct pacing of the myocardium." @default.
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- W2073026462 date "2005-05-01" @default.
- W2073026462 modified "2023-09-27" @default.
- W2073026462 title "Action potential duration restitution during sympathetic nerve stimulation versus pacing" @default.
- W2073026462 doi "https://doi.org/10.1016/j.hrthm.2005.02.808" @default.
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