FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073039230> ?p ?o ?g. }

• W2073039230 endingPage "1731" @default.
• W2073039230 startingPage "1724" @default.
• W2073039230 abstract "Soft tissue sarcomas (STS) are characterized by co-participation of several epigenetic and genetic events during tumorigenesis. Having bypassed cellular senescence barriers during oncogenic transformation, the factors further affecting growth rate of STS cells remain poorly understood. Therefore, we investigated the role of gene silencing (DNA promoter methylation of LINE-1, PTEN), genetic aberrations (karyotype, KRAS and BRAF mutations) as well as their contribution to the proliferation rate and migratory potential that underlies “initial” and “final” passage sarcoma cells. Three different cell lines were used, SW982 (synovial sarcoma), U2197 (malignant fibrous histiocytoma (MFH)) and HT1080 (fibrosarcoma). Increased proliferative potential of final passage STS cells was not associated with significant differences in methylation (LINE-1, PTEN) and mutation status (KRAS, BRAF), but it was dependent on the amount of chromosomal aberrations. Collectively, our data demonstrate that these fairly differentiated/advanced cancer cell lines have still the potential to gain an additional spontaneous growth benefit without external influences and that maintenance of increased proliferative potential towards longevity of STS cells (having crossed senescence barriers) may be independent of overt epigenetic alterations." @default.
• W2073039230 created "2016-06-24" @default.
• W2073039230 creator A5009106404 @default.
• W2073039230 creator A5013817224 @default.
• W2073039230 creator A5024447480 @default.
• W2073039230 creator A5025452509 @default.
• W2073039230 creator A5031403380 @default.
• W2073039230 creator A5041282324 @default.
• W2073039230 creator A5053155529 @default.
• W2073039230 creator A5063413978 @default.
• W2073039230 creator A5068740244 @default.
• W2073039230 creator A5071506845 @default.
• W2073039230 creator A5076892602 @default.
• W2073039230 creator A5088641646 @default.
• W2073039230 date "2013-07-01" @default.
• W2073039230 modified "2023-09-26" @default.
• W2073039230 title "Growth rate of late passage sarcoma cells is independent of epigenetic events but dependent on the amount of chromosomal aberrations" @default.
• W2073039230 cites W1986083764 @default.
• W2073039230 cites W1987760376 @default.
• W2073039230 cites W1998884405 @default.
• W2073039230 cites W2008900878 @default.
• W2073039230 cites W2009554628 @default.
• W2073039230 cites W2028994134 @default.
• W2073039230 cites W2034303286 @default.
• W2073039230 cites W2035505168 @default.
• W2073039230 cites W2051541780 @default.
• W2073039230 cites W2054824587 @default.
• W2073039230 cites W2060864401 @default.
• W2073039230 cites W2073353870 @default.
• W2073039230 cites W2105672290 @default.
• W2073039230 cites W2118002947 @default.
• W2073039230 cites W2150269898 @default.
• W2073039230 doi "https://doi.org/10.1016/j.yexcr.2013.03.023" @default.
• W2073039230 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23535008" @default.
• W2073039230 hasPublicationYear "2013" @default.
• W2073039230 type Work @default.
• W2073039230 sameAs 2073039230 @default.
• W2073039230 citedByCount "9" @default.
• W2073039230 countsByYear W20730392302014 @default.
• W2073039230 countsByYear W20730392302016 @default.
• W2073039230 countsByYear W20730392302017 @default.
• W2073039230 countsByYear W20730392302018 @default.
• W2073039230 countsByYear W20730392302019 @default.
• W2073039230 countsByYear W20730392302020 @default.
• W2073039230 crossrefType "journal-article" @default.
• W2073039230 hasAuthorship W2073039230A5009106404 @default.
• W2073039230 hasAuthorship W2073039230A5013817224 @default.
• W2073039230 hasAuthorship W2073039230A5024447480 @default.
• W2073039230 hasAuthorship W2073039230A5025452509 @default.
• W2073039230 hasAuthorship W2073039230A5031403380 @default.
• W2073039230 hasAuthorship W2073039230A5041282324 @default.
• W2073039230 hasAuthorship W2073039230A5053155529 @default.
• W2073039230 hasAuthorship W2073039230A5063413978 @default.
• W2073039230 hasAuthorship W2073039230A5068740244 @default.
• W2073039230 hasAuthorship W2073039230A5071506845 @default.
• W2073039230 hasAuthorship W2073039230A5076892602 @default.
• W2073039230 hasAuthorship W2073039230A5088641646 @default.
• W2073039230 hasConcept C104317684 @default.
• W2073039230 hasConcept C121608353 @default.
• W2073039230 hasConcept C142724271 @default.
• W2073039230 hasConcept C150194340 @default.
• W2073039230 hasConcept C177336024 @default.
• W2073039230 hasConcept C190727270 @default.
• W2073039230 hasConcept C2776910622 @default.
• W2073039230 hasConcept C2778256501 @default.
• W2073039230 hasConcept C2781187634 @default.
• W2073039230 hasConcept C41091548 @default.
• W2073039230 hasConcept C501734568 @default.
• W2073039230 hasConcept C502942594 @default.
• W2073039230 hasConcept C522857546 @default.
• W2073039230 hasConcept C54355233 @default.
• W2073039230 hasConcept C555283112 @default.
• W2073039230 hasConcept C71924100 @default.
• W2073039230 hasConcept C86803240 @default.
• W2073039230 hasConceptScore W2073039230C104317684 @default.
• W2073039230 hasConceptScore W2073039230C121608353 @default.
• W2073039230 hasConceptScore W2073039230C142724271 @default.
• W2073039230 hasConceptScore W2073039230C150194340 @default.
• W2073039230 hasConceptScore W2073039230C177336024 @default.
• W2073039230 hasConceptScore W2073039230C190727270 @default.
• W2073039230 hasConceptScore W2073039230C2776910622 @default.
• W2073039230 hasConceptScore W2073039230C2778256501 @default.
• W2073039230 hasConceptScore W2073039230C2781187634 @default.
• W2073039230 hasConceptScore W2073039230C41091548 @default.
• W2073039230 hasConceptScore W2073039230C501734568 @default.
• W2073039230 hasConceptScore W2073039230C502942594 @default.
• W2073039230 hasConceptScore W2073039230C522857546 @default.
• W2073039230 hasConceptScore W2073039230C54355233 @default.
• W2073039230 hasConceptScore W2073039230C555283112 @default.
• W2073039230 hasConceptScore W2073039230C71924100 @default.
• W2073039230 hasConceptScore W2073039230C86803240 @default.
• W2073039230 hasIssue "12" @default.
• W2073039230 hasLocation W20730392301 @default.
• W2073039230 hasLocation W20730392302 @default.
• W2073039230 hasOpenAccess W2073039230 @default.
• W2073039230 hasPrimaryLocation W20730392301 @default.
• W2073039230 hasRelatedWork W110103515 @default.
• W2073039230 hasRelatedWork W2018365251 @default.

• next