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- W2073042817 endingPage "264" @default.
- W2073042817 startingPage "249" @default.
- W2073042817 abstract "Infection with <i>Helicobacter pylori</i> is established as the major risk factor for gastric cancer development. Damage of the mucosal barrier due to <i>H. pylori</i>-induced inflammation enhances the carcinogenic effect of other risk factors such as salt intake or tobacco smoking. The genetic disposition of both the bacterial strain and the host can increase the potential towards gastric cancer formation. Genetic variance of the bacterial proteins CagA and VacA is associated with a higher gastric cancer risk, as are polymorphisms and epigenetic changes in host gene coding for interleukins (IL1β, IL8), transcription factors (CDX2, RUNX3) and DNA repair enzymes. Application of high-throughput assays for genome-wide assessment of either genetic structural variance or gene expression patterns may lead to a better understanding of the pathobiological background of these processes, including the underlying signaling pathways. Understanding of the stepwise alterations that take place in the transition from chronic atrophic gastritis, via metaplastic changes, to invasive neoplasia is vital to define the ‘point of no return' before which eradication of <i>H. pylori </i>has the potential to prevent gastric cancer. Currently, eradication as preventive strategy is only recommended for high-incidence regions in Asia; large population studies with an adequate follow-up are required to demonstrate the effectiveness of such an approach in Western populations." @default.
- W2073042817 created "2016-06-24" @default.
- W2073042817 creator A5006570732 @default.
- W2073042817 creator A5048446588 @default.
- W2073042817 date "2014-01-01" @default.
- W2073042817 modified "2023-10-04" @default.
- W2073042817 title "Helicobacter pylori and Gastric Cancer" @default.
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