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- W2073048205 endingPage "289" @default.
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- W2073048205 abstract "Microglial cell activation is a rapidly occurring cellular response to cerebral ischaemia. Microglia proliferate, are recruited to the site of lesion, npregulate the expression of several surface molecules including major histocom-patibility complex class I and II antigens, complement receptor and the amyloid precursor protein (APP) as well as newly expressed cytokines, e.g. interleukin-1 and transforming growth factor pl. The ischaemia-induced production of APP may contribute to amyloid deposition in the aged brain under conditions of hypofusion. Ultra-structurally, microglia transform into phagocytes removing necrotic neurons but still respecting the integrity of eventually surviving neurons even in the close vicinity of necrotic neurons. Microglial activation starts within a few minutes after ischaemia and thus precedes the morphologically detectable neuronal damage. It additionally involves a transient generalized response within the first 24 hours post-ischaemia even at sites without eventual neuronal cell death. In functional terms, the microglial reaction appears to be a double-edged sword in ischaemia. Activated microglia may exert a cytotoxic effector function by releasing reactive oxygen species, nitric oxide, proteinases or inflammatory cytokines. All of these cytotoxic compounds may cause bystander damage following ischaemia. Pharmacological suppression of microglial activation after ischaemia has accordingly attenuated the extent of cell death and tissue damage. However, activated microglia support tissue repair by secreting factors such as transforming growth factor βl which may limit tissue damage as well as suppress astroglial scar formation. In line with ultrastructural observations microglial activation in ischaemia is a strictly controlled event. By secreting cytokines and growth factors activated microglia most likely serve seemingly opposed functions in ischaemia, i.e. maintenance as well as removal of injured neurons. Post-ischaemic pharmacological modulation of microglial intervention in the cascade of events that lead to neuronal necrosis may help to improve the structural and functional outcome following CNS ischaemia." @default.
- W2073048205 created "2016-06-24" @default.
- W2073048205 creator A5017363315 @default.
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- W2073048205 creator A5090318543 @default.
- W2073048205 date "1995-08-01" @default.
- W2073048205 modified "2023-10-09" @default.
- W2073048205 title "Reactive microglia in cerebral ischaemia: an early mediator of tissue damage?" @default.
- W2073048205 cites W1519463096 @default.
- W2073048205 cites W1573205528 @default.
- W2073048205 cites W1906640112 @default.
- W2073048205 cites W1923107093 @default.
- W2073048205 cites W1965438773 @default.
- W2073048205 cites W1968563892 @default.
- W2073048205 cites W1969221865 @default.
- W2073048205 cites W1970773611 @default.
- W2073048205 cites W1975603938 @default.
- W2073048205 cites W1975896299 @default.
- W2073048205 cites W1976953547 @default.
- W2073048205 cites W1980723823 @default.
- W2073048205 cites W1980920786 @default.
- W2073048205 cites W1985315203 @default.
- W2073048205 cites W1985439588 @default.
- W2073048205 cites W1985530741 @default.
- W2073048205 cites W1987031160 @default.
- W2073048205 cites W1989954752 @default.
- W2073048205 cites W1992656563 @default.
- W2073048205 cites W1994085010 @default.
- W2073048205 cites W1994426001 @default.
- W2073048205 cites W1999881215 @default.
- W2073048205 cites W2014687403 @default.
- W2073048205 cites W2015550320 @default.
- W2073048205 cites W2016977117 @default.
- W2073048205 cites W2019900217 @default.
- W2073048205 cites W2021533801 @default.
- W2073048205 cites W2021812498 @default.
- W2073048205 cites W2022224035 @default.
- W2073048205 cites W2023003439 @default.
- W2073048205 cites W2023396428 @default.
- W2073048205 cites W2024276630 @default.
- W2073048205 cites W2024438684 @default.
- W2073048205 cites W2025326202 @default.
- W2073048205 cites W2025392129 @default.
- W2073048205 cites W2025461456 @default.
- W2073048205 cites W2025638147 @default.
- W2073048205 cites W2029549981 @default.
- W2073048205 cites W2029629215 @default.
- W2073048205 cites W2029686424 @default.
- W2073048205 cites W2031178299 @default.
- W2073048205 cites W2031925670 @default.
- W2073048205 cites W2032504205 @default.
- W2073048205 cites W2033703126 @default.
- W2073048205 cites W2036699057 @default.
- W2073048205 cites W2037604538 @default.
- W2073048205 cites W2038509428 @default.
- W2073048205 cites W2039682406 @default.
- W2073048205 cites W2040506163 @default.
- W2073048205 cites W2042177793 @default.
- W2073048205 cites W2042393284 @default.
- W2073048205 cites W2042824134 @default.
- W2073048205 cites W2043725292 @default.
- W2073048205 cites W2043736935 @default.
- W2073048205 cites W2043985705 @default.
- W2073048205 cites W2045738785 @default.
- W2073048205 cites W2046335509 @default.
- W2073048205 cites W2049529908 @default.
- W2073048205 cites W2049618347 @default.
- W2073048205 cites W2052757882 @default.
- W2073048205 cites W2053765138 @default.
- W2073048205 cites W2054113452 @default.
- W2073048205 cites W2054353872 @default.
- W2073048205 cites W2054638295 @default.
- W2073048205 cites W2055637018 @default.
- W2073048205 cites W2062160494 @default.
- W2073048205 cites W2062265210 @default.
- W2073048205 cites W2064645610 @default.
- W2073048205 cites W2070730444 @default.
- W2073048205 cites W2070732771 @default.
- W2073048205 cites W2071141883 @default.
- W2073048205 cites W2074022605 @default.
- W2073048205 cites W2076162707 @default.
- W2073048205 cites W2076659607 @default.
- W2073048205 cites W2080558822 @default.
- W2073048205 cites W2082011784 @default.
- W2073048205 cites W2082798955 @default.
- W2073048205 cites W2084861350 @default.
- W2073048205 cites W2085089983 @default.
- W2073048205 cites W2085092012 @default.
- W2073048205 cites W2086129363 @default.
- W2073048205 cites W2086148521 @default.
- W2073048205 cites W2088792561 @default.
- W2073048205 cites W2090163805 @default.
- W2073048205 cites W2099233769 @default.
- W2073048205 cites W2104660263 @default.
- W2073048205 cites W2106829291 @default.
- W2073048205 cites W2112836421 @default.