Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073052953> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2073052953 endingPage "806" @default.
- W2073052953 startingPage "803" @default.
- W2073052953 abstract "Whole-genome studies have identified several intronic single nucleotide polymorphisms (SNPs) in SLCO1B1 associated with simvastatin-induced myopathy. The present study determined the effect of an intronic SNP rs4149081 in SLCO1B1 on the lipid-lowering effects of simvastatin and rosuvastatin in Chinese patients with hypercholesterolaemia. Lipid profiles were determined off treatment and after at least 4 weeks of treatment with each of the statins at daily doses of rosuvastatin 10 mg and simvastatin 40 mg. In 247 patients with good adherence, the rs4149081 G>A polymorphism was significantly associated with a 4.6 and 4.0% greater low-density lipoprotein cholesterol (LDL-C) reduction compared with those with wild-type alleles in response to rosuvastatin and simvastatin, respectively (P<0.05 for both). The 388A>G and 521T>C polymorphisms were not associated with the LDL-C response to either statin. The intronic SNP rs4149081 in SLCO1B1 was associated with the LDL-C response to statins in Chinese patients and this association was independent of the 521T>C polymorphism." @default.
- W2073052953 created "2016-06-24" @default.
- W2073052953 creator A5003968624 @default.
- W2073052953 creator A5034171480 @default.
- W2073052953 creator A5068775883 @default.
- W2073052953 date "2012-11-01" @default.
- W2073052953 modified "2023-10-11" @default.
- W2073052953 title "Intronic variants in SLCO1B1 related to statin-induced myopathy are associated with the low-density lipoprotein cholesterol response to statins in Chinese patients with hyperlipidaemia" @default.
- W2073052953 cites W1604547439 @default.
- W2073052953 cites W2011911793 @default.
- W2073052953 cites W2015646872 @default.
- W2073052953 cites W2038526706 @default.
- W2073052953 cites W2079296200 @default.
- W2073052953 cites W2085658412 @default.
- W2073052953 cites W2095010499 @default.
- W2073052953 cites W2101501447 @default.
- W2073052953 cites W2113719939 @default.
- W2073052953 doi "https://doi.org/10.1097/fpc.0b013e3283557c98" @default.
- W2073052953 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22668755" @default.
- W2073052953 hasPublicationYear "2012" @default.
- W2073052953 type Work @default.
- W2073052953 sameAs 2073052953 @default.
- W2073052953 citedByCount "17" @default.
- W2073052953 countsByYear W20730529532013 @default.
- W2073052953 countsByYear W20730529532014 @default.
- W2073052953 countsByYear W20730529532015 @default.
- W2073052953 countsByYear W20730529532016 @default.
- W2073052953 countsByYear W20730529532019 @default.
- W2073052953 countsByYear W20730529532020 @default.
- W2073052953 countsByYear W20730529532021 @default.
- W2073052953 countsByYear W20730529532022 @default.
- W2073052953 countsByYear W20730529532023 @default.
- W2073052953 crossrefType "journal-article" @default.
- W2073052953 hasAuthorship W2073052953A5003968624 @default.
- W2073052953 hasAuthorship W2073052953A5034171480 @default.
- W2073052953 hasAuthorship W2073052953A5068775883 @default.
- W2073052953 hasConcept C104317684 @default.
- W2073052953 hasConcept C126322002 @default.
- W2073052953 hasConcept C135763542 @default.
- W2073052953 hasConcept C139275648 @default.
- W2073052953 hasConcept C149737253 @default.
- W2073052953 hasConcept C153209595 @default.
- W2073052953 hasConcept C180754005 @default.
- W2073052953 hasConcept C2776329913 @default.
- W2073052953 hasConcept C2776598434 @default.
- W2073052953 hasConcept C2776839432 @default.
- W2073052953 hasConcept C2777300911 @default.
- W2073052953 hasConcept C2777482532 @default.
- W2073052953 hasConcept C2778163477 @default.
- W2073052953 hasConcept C2780499067 @default.
- W2073052953 hasConcept C54355233 @default.
- W2073052953 hasConcept C55775858 @default.
- W2073052953 hasConcept C71924100 @default.
- W2073052953 hasConcept C86803240 @default.
- W2073052953 hasConcept C98274493 @default.
- W2073052953 hasConceptScore W2073052953C104317684 @default.
- W2073052953 hasConceptScore W2073052953C126322002 @default.
- W2073052953 hasConceptScore W2073052953C135763542 @default.
- W2073052953 hasConceptScore W2073052953C139275648 @default.
- W2073052953 hasConceptScore W2073052953C149737253 @default.
- W2073052953 hasConceptScore W2073052953C153209595 @default.
- W2073052953 hasConceptScore W2073052953C180754005 @default.
- W2073052953 hasConceptScore W2073052953C2776329913 @default.
- W2073052953 hasConceptScore W2073052953C2776598434 @default.
- W2073052953 hasConceptScore W2073052953C2776839432 @default.
- W2073052953 hasConceptScore W2073052953C2777300911 @default.
- W2073052953 hasConceptScore W2073052953C2777482532 @default.
- W2073052953 hasConceptScore W2073052953C2778163477 @default.
- W2073052953 hasConceptScore W2073052953C2780499067 @default.
- W2073052953 hasConceptScore W2073052953C54355233 @default.
- W2073052953 hasConceptScore W2073052953C55775858 @default.
- W2073052953 hasConceptScore W2073052953C71924100 @default.
- W2073052953 hasConceptScore W2073052953C86803240 @default.
- W2073052953 hasConceptScore W2073052953C98274493 @default.
- W2073052953 hasIssue "11" @default.
- W2073052953 hasLocation W20730529531 @default.
- W2073052953 hasLocation W20730529532 @default.
- W2073052953 hasOpenAccess W2073052953 @default.
- W2073052953 hasPrimaryLocation W20730529531 @default.
- W2073052953 hasRelatedWork W2018561477 @default.
- W2073052953 hasRelatedWork W2173847973 @default.
- W2073052953 hasRelatedWork W2351021447 @default.
- W2073052953 hasRelatedWork W2387469548 @default.
- W2073052953 hasRelatedWork W2468106161 @default.
- W2073052953 hasRelatedWork W2966600289 @default.
- W2073052953 hasRelatedWork W2981331699 @default.
- W2073052953 hasRelatedWork W4211137976 @default.
- W2073052953 hasRelatedWork W4323347375 @default.
- W2073052953 hasRelatedWork W2550230000 @default.
- W2073052953 hasVolume "22" @default.
- W2073052953 isParatext "false" @default.
- W2073052953 isRetracted "false" @default.
- W2073052953 magId "2073052953" @default.
- W2073052953 workType "article" @default.