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- W2073055692 abstract "Abstract When testing the noninferiority of an experimental treatment to a standard (or control) treatment in a randomized clinical trial (RCT), we may come across the outcomes of patient response on an ordinal scale. We focus our discussion on testing noninferiority in ordinal data for an RCT under the parallel groups design. We develop simple test procedures based on the generalized odds ratio (GOR). We note that these test procedures not only can account for the information on the order of ordinal responses without assuming any specific parametric structural model, but also can be independent of any arbitrarily subjective scoring system. We further develop sample size determination based on the test procedure using the GOR. We apply Monte Carlo simulation to evaluate the performance of these test procedures and the accuracy of sample size calculation formula proposed here in a variety of situations. Finally, we employ the data taken from a trial comparing once-daily gatifloxican with three-times-daily co-amoxiclav in the treatment of community-acquired pneumonia to illustrate the use of these test procedures and sample size calculation formula. Key Words: Generalized odds ratioNoninferiorityOrdinal dataParallel groups design ACKNOWLEDGMENTS The authors thank the two referees for many useful and helpful comments to improve the contents and clarity of this article." @default.
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- W2073055692 date "2013-10-18" @default.
- W2073055692 modified "2023-09-24" @default.
- W2073055692 title "Notes on Testing Noninferiority in Ordinal Data Under the Parallel Groups Design" @default.
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- W2073055692 doi "https://doi.org/10.1080/10543406.2013.834923" @default.
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