Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073068667> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2073068667 endingPage "434" @default.
- W2073068667 startingPage "426" @default.
- W2073068667 abstract "The melanotrope population of the frog intermediate lobe consists of two subtypes of cells, referred to as high-(HD) and low-density (LD) melanotrope cells, which differ markedly in their basal morphofunctional features as well as their in vitro response to hypothalamic factors, such as the stimulator thyrotropin-releasing hormone (TRH) and the inhibitor dopamine. In this study, we have investigated whether other major hypothalamic regulators of the release of alpha-melanocyte-stimulating hormone (alpha-MSH), such as gamma-aminobutyric acid (GABA) and neuropeptide Y (NPY), also differentially regulate frog melanotrope subpopulations. Our results show that in LD cells, both factors markedly inhibited proopiomelanocortin (POMC) mRNA accumulation and alpha-MSH secretion. In contrast, the secretory and biosynthetic activity of HD cells was not modified by GABA. NPY inhibited POMC transcript accumulation and tended to reduce alpha-MSH secretion in HD cells, yet these effects were less pronounced than those evoked in LD cells. In addition, GABA and NPY inhibited the KCl-induced rise in cytosolic free calcium levels in both subpopulations. Taken together, these results further indicate that frog melanotrope subpopulations are differentially regulated by the hypothalamus and strongly suggest that the intensity of such regulation is directly related to the activity of the cell subset. Thus, the LD subpopulation represents a highly responsive cell subset which is regulated by multiple neuroendocrine factors (TRH, dopamine, GABA and NPY), whereas the hormone storage HD subpopulation shows a moderate response to single stimulatory (TRH) and inhibitory (NPY) inputs." @default.
- W2073068667 created "2016-06-24" @default.
- W2073068667 creator A5015125277 @default.
- W2073068667 creator A5019349454 @default.
- W2073068667 creator A5055539271 @default.
- W2073068667 creator A5056002447 @default.
- W2073068667 creator A5059027410 @default.
- W2073068667 creator A5086915323 @default.
- W2073068667 date "2001-01-01" @default.
- W2073068667 modified "2023-09-26" @default.
- W2073068667 title "Amphibian Melanotrope Subpopulations Respond Differentially to Hypothalamic Secreto-Inhibitors" @default.
- W2073068667 cites W1969332056 @default.
- W2073068667 cites W1973178609 @default.
- W2073068667 cites W1980780685 @default.
- W2073068667 cites W1991373026 @default.
- W2073068667 cites W1997815277 @default.
- W2073068667 cites W2003317484 @default.
- W2073068667 cites W2009056786 @default.
- W2073068667 cites W2016777399 @default.
- W2073068667 cites W2035943706 @default.
- W2073068667 cites W2042708415 @default.
- W2073068667 cites W2080322999 @default.
- W2073068667 cites W2088495020 @default.
- W2073068667 cites W2136067737 @default.
- W2073068667 doi "https://doi.org/10.1159/000054661" @default.
- W2073068667 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11408784" @default.
- W2073068667 hasPublicationYear "2001" @default.
- W2073068667 type Work @default.
- W2073068667 sameAs 2073068667 @default.
- W2073068667 citedByCount "7" @default.
- W2073068667 countsByYear W20730686672022 @default.
- W2073068667 crossrefType "journal-article" @default.
- W2073068667 hasAuthorship W2073068667A5015125277 @default.
- W2073068667 hasAuthorship W2073068667A5019349454 @default.
- W2073068667 hasAuthorship W2073068667A5055539271 @default.
- W2073068667 hasAuthorship W2073068667A5056002447 @default.
- W2073068667 hasAuthorship W2073068667A5059027410 @default.
- W2073068667 hasAuthorship W2073068667A5086915323 @default.
- W2073068667 hasConcept C118303440 @default.
- W2073068667 hasConcept C126322002 @default.
- W2073068667 hasConcept C134018914 @default.
- W2073068667 hasConcept C144024400 @default.
- W2073068667 hasConcept C149923435 @default.
- W2073068667 hasConcept C170493617 @default.
- W2073068667 hasConcept C2777003273 @default.
- W2073068667 hasConcept C2777658017 @default.
- W2073068667 hasConcept C2780017199 @default.
- W2073068667 hasConcept C2780989459 @default.
- W2073068667 hasConcept C2781309135 @default.
- W2073068667 hasConcept C2908647359 @default.
- W2073068667 hasConcept C513476851 @default.
- W2073068667 hasConcept C71315377 @default.
- W2073068667 hasConcept C71924100 @default.
- W2073068667 hasConcept C86803240 @default.
- W2073068667 hasConcept C93984277 @default.
- W2073068667 hasConceptScore W2073068667C118303440 @default.
- W2073068667 hasConceptScore W2073068667C126322002 @default.
- W2073068667 hasConceptScore W2073068667C134018914 @default.
- W2073068667 hasConceptScore W2073068667C144024400 @default.
- W2073068667 hasConceptScore W2073068667C149923435 @default.
- W2073068667 hasConceptScore W2073068667C170493617 @default.
- W2073068667 hasConceptScore W2073068667C2777003273 @default.
- W2073068667 hasConceptScore W2073068667C2777658017 @default.
- W2073068667 hasConceptScore W2073068667C2780017199 @default.
- W2073068667 hasConceptScore W2073068667C2780989459 @default.
- W2073068667 hasConceptScore W2073068667C2781309135 @default.
- W2073068667 hasConceptScore W2073068667C2908647359 @default.
- W2073068667 hasConceptScore W2073068667C513476851 @default.
- W2073068667 hasConceptScore W2073068667C71315377 @default.
- W2073068667 hasConceptScore W2073068667C71924100 @default.
- W2073068667 hasConceptScore W2073068667C86803240 @default.
- W2073068667 hasConceptScore W2073068667C93984277 @default.
- W2073068667 hasIssue "6" @default.
- W2073068667 hasLocation W20730686671 @default.
- W2073068667 hasLocation W20730686672 @default.
- W2073068667 hasOpenAccess W2073068667 @default.
- W2073068667 hasPrimaryLocation W20730686671 @default.
- W2073068667 hasRelatedWork W1967501438 @default.
- W2073068667 hasRelatedWork W1981396719 @default.
- W2073068667 hasRelatedWork W1981897232 @default.
- W2073068667 hasRelatedWork W2069250032 @default.
- W2073068667 hasRelatedWork W2070813616 @default.
- W2073068667 hasRelatedWork W2075311889 @default.
- W2073068667 hasRelatedWork W2080251505 @default.
- W2073068667 hasRelatedWork W2109861165 @default.
- W2073068667 hasRelatedWork W2586307018 @default.
- W2073068667 hasRelatedWork W4240276219 @default.
- W2073068667 hasVolume "73" @default.
- W2073068667 isParatext "false" @default.
- W2073068667 isRetracted "false" @default.
- W2073068667 magId "2073068667" @default.
- W2073068667 workType "article" @default.