FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073069613> ?p ?o ?g. }

• W2073069613 endingPage "700" @default.
• W2073069613 startingPage "692" @default.
• W2073069613 abstract "Mobilization of remyelinating cells spontaneously occurs in the adult brain. These cellular resources are specially active after demyelinating episodes in early phases of multiple sclerosis (MS). Indeed, oligodendrocyte precursor cells (OPCs) actively proliferate, migrate to and repopulate the lesioned areas. Ultimately, efficient remyelination is accomplished when new oligodendrocytes reinvest nude neuronal axons, restoring the normal properties of impulse conduction. As the disease progresses this fundamental process fails. Multiple causes seem to contribute to such transient decline, including the failure of OPCs to differentiate and enwrap the vulnerable neuronal axons. Regenerative medicine for MS has been mainly centered on the recruitment of endogenous self-repair mechanisms, or on transplantation approaches. The latter commonly involves grafting of neural precursor cells (NPCs) or neural stem cells (NSCs), with myelinogenic potential, in the injured areas. Both strategies require further understanding of the biology of oligodendrocyte differentiation and remyelination. Indeed, the success of transplantation largely depends on the pre-commitment of transplanted NPCs or NSCs into oligodendroglial cell type, while the endogenous differentiation of OPCs needs to be boosted in chronic stages of the disease. Thus, much effort has been focused on finding molecular targets that drive oligodendrocytes commitment and development. The present review explores several aspects of remyelination that must be considered in the design of a cell-based therapy for MS, and explores more deeply the challenge of fostering oligodendrogenesis. In this regard, we discuss herein a tool developed in our research group useful to search novel oligodendrogenic factors and to study oligodendrocyte differentiation in a time- and cost-saving manner." @default.
• W2073069613 created "2016-06-24" @default.
• W2073069613 creator A5052244043 @default.
• W2073069613 creator A5087994541 @default.
• W2073069613 creator A5088052374 @default.
• W2073069613 date "2013-01-19" @default.
• W2073069613 modified "2023-09-27" @default.
• W2073069613 title "Oligodendrogenesis from neural stem cells: Perspectives for remyelinating strategies" @default.
• W2073069613 cites W1541342760 @default.
• W2073069613 cites W1738662589 @default.
• W2073069613 cites W1760682360 @default.
• W2073069613 cites W1866034006 @default.
• W2073069613 cites W1900556344 @default.
• W2073069613 cites W1968387549 @default.
• W2073069613 cites W1968427756 @default.
• W2073069613 cites W1968977740 @default.
• W2073069613 cites W1970720216 @default.
• W2073069613 cites W1971728959 @default.
• W2073069613 cites W1972856118 @default.
• W2073069613 cites W1980286364 @default.
• W2073069613 cites W1981371990 @default.
• W2073069613 cites W1986103597 @default.
• W2073069613 cites W1986420581 @default.
• W2073069613 cites W1987057401 @default.
• W2073069613 cites W1987270591 @default.
• W2073069613 cites W1988723810 @default.
• W2073069613 cites W1989398840 @default.
• W2073069613 cites W1990914863 @default.
• W2073069613 cites W1993870167 @default.
• W2073069613 cites W1997664696 @default.
• W2073069613 cites W2007202464 @default.
• W2073069613 cites W2007438030 @default.
• W2073069613 cites W2010887753 @default.
• W2073069613 cites W2013152746 @default.
• W2073069613 cites W2013681684 @default.
• W2073069613 cites W2015645731 @default.
• W2073069613 cites W2017326823 @default.
• W2073069613 cites W2018031743 @default.
• W2073069613 cites W2020452847 @default.
• W2073069613 cites W2020539766 @default.
• W2073069613 cites W2023258827 @default.
• W2073069613 cites W2026159064 @default.
• W2073069613 cites W2026571378 @default.
• W2073069613 cites W2027274730 @default.
• W2073069613 cites W2029647615 @default.
• W2073069613 cites W2030377258 @default.
• W2073069613 cites W2034631388 @default.
• W2073069613 cites W2036045423 @default.
• W2073069613 cites W2036675289 @default.
• W2073069613 cites W2044948946 @default.
• W2073069613 cites W2045155944 @default.
• W2073069613 cites W2045341846 @default.
• W2073069613 cites W2047692601 @default.
• W2073069613 cites W2047850628 @default.
• W2073069613 cites W2048082433 @default.
• W2073069613 cites W2050713728 @default.
• W2073069613 cites W2051575838 @default.
• W2073069613 cites W2058358434 @default.
• W2073069613 cites W2063913521 @default.
• W2073069613 cites W2064953489 @default.
• W2073069613 cites W2066356973 @default.
• W2073069613 cites W2068969996 @default.
• W2073069613 cites W2069958858 @default.
• W2073069613 cites W2074609567 @default.
• W2073069613 cites W2083229277 @default.
• W2073069613 cites W2084887202 @default.
• W2073069613 cites W2085383857 @default.
• W2073069613 cites W2085909311 @default.
• W2073069613 cites W2087523259 @default.
• W2073069613 cites W2094613247 @default.
• W2073069613 cites W2100119722 @default.
• W2073069613 cites W2100904149 @default.
• W2073069613 cites W2113795250 @default.
• W2073069613 cites W2116435511 @default.
• W2073069613 cites W2116532218 @default.
• W2073069613 cites W2118108707 @default.
• W2073069613 cites W2122417496 @default.
• W2073069613 cites W2124758555 @default.
• W2073069613 cites W2125987139 @default.
• W2073069613 cites W2131298130 @default.
• W2073069613 cites W2139321372 @default.
• W2073069613 cites W2141254780 @default.
• W2073069613 cites W2144540270 @default.
• W2073069613 cites W2145925994 @default.
• W2073069613 cites W2147062889 @default.
• W2073069613 cites W2147195797 @default.
• W2073069613 cites W2147352258 @default.
• W2073069613 cites W2150569013 @default.
• W2073069613 cites W2152131288 @default.
• W2073069613 cites W2155201436 @default.
• W2073069613 cites W2157419121 @default.
• W2073069613 cites W2157780675 @default.
• W2073069613 cites W2159029645 @default.
• W2073069613 cites W2163640310 @default.
• W2073069613 cites W2164237816 @default.
• W2073069613 cites W2170308912 @default.
• W2073069613 cites W2175175849 @default.
• W2073069613 cites W2405191593 @default.

• next