Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073072010> ?p ?o ?g. }
- W2073072010 endingPage "e1002117" @default.
- W2073072010 startingPage "e1002117" @default.
- W2073072010 abstract "Many enteric pathogens are equipped with multiple cell adhesion factors which are important for host tissue colonization and virulence. Y. enterocolitica, a common food-borne pathogen with invasive properties, uses the surface proteins invasin and YadA for host cell binding and entry. In this study, we demonstrate unique cell adhesion and invasion properties of Y. enterocolitica serotype O:3 strains, the most frequent cause of human yersiniosis, and show that these differences are mainly attributable to variations affecting the function and expression of invasin in response to temperature. In contrast to other enteric Yersinia strains, invasin production in O:3 strains is constitutive and largely enhanced compared to other Y. enterocolitica serotypes, in which invA expression is temperature-regulated and significantly reduced at 37°C. Increase of invasin levels is caused by (i) an IS1667 insertion into the invA promoter region, which includes an additional promoter and RovA and H-NS binding sites, and (ii) a P98S substitution in the invA activator protein RovA rendering the regulator less susceptible to proteolysis. Both variations were shown to influence bacterial colonization in a murine infection model. Furthermore, we found that co-expression of YadA and down-regulation of the O-antigen at 37°C is required to allow efficient internalization by the InvA protein. We conclude that even small variations in the expression of virulence factors can provoke a major difference in the virulence properties of closely related pathogens which may confer better survival or a higher pathogenic potential in a certain host or host environment." @default.
- W2073072010 created "2016-06-24" @default.
- W2073072010 creator A5006800420 @default.
- W2073072010 creator A5016986473 @default.
- W2073072010 creator A5023816801 @default.
- W2073072010 creator A5025349630 @default.
- W2073072010 creator A5051375625 @default.
- W2073072010 creator A5054215036 @default.
- W2073072010 creator A5060352582 @default.
- W2073072010 creator A5061433515 @default.
- W2073072010 creator A5064355099 @default.
- W2073072010 creator A5078759067 @default.
- W2073072010 creator A5082204293 @default.
- W2073072010 creator A5083529958 @default.
- W2073072010 date "2011-07-07" @default.
- W2073072010 modified "2023-10-06" @default.
- W2073072010 title "Unique Cell Adhesion and Invasion Properties of Yersinia enterocolitica O:3, the Most Frequent Cause of Human Yersiniosis" @default.
- W2073072010 cites W1015503723 @default.
- W2073072010 cites W1221506603 @default.
- W2073072010 cites W1483384893 @default.
- W2073072010 cites W1490761102 @default.
- W2073072010 cites W1552039422 @default.
- W2073072010 cites W1552804394 @default.
- W2073072010 cites W1817627349 @default.
- W2073072010 cites W1873199501 @default.
- W2073072010 cites W1895298627 @default.
- W2073072010 cites W1901220190 @default.
- W2073072010 cites W1903506151 @default.
- W2073072010 cites W1926745701 @default.
- W2073072010 cites W1946080788 @default.
- W2073072010 cites W1961487352 @default.
- W2073072010 cites W1969540615 @default.
- W2073072010 cites W1980752412 @default.
- W2073072010 cites W1984066183 @default.
- W2073072010 cites W1985024909 @default.
- W2073072010 cites W1992410305 @default.
- W2073072010 cites W1994852714 @default.
- W2073072010 cites W1995389351 @default.
- W2073072010 cites W1997062953 @default.
- W2073072010 cites W1997074046 @default.
- W2073072010 cites W2000513690 @default.
- W2073072010 cites W2010849870 @default.
- W2073072010 cites W2011593226 @default.
- W2073072010 cites W2018141970 @default.
- W2073072010 cites W2019305946 @default.
- W2073072010 cites W2027200042 @default.
- W2073072010 cites W2027229485 @default.
- W2073072010 cites W2030813162 @default.
- W2073072010 cites W2033883874 @default.
- W2073072010 cites W2039709337 @default.
- W2073072010 cites W2044025320 @default.
- W2073072010 cites W2052875067 @default.
- W2073072010 cites W2060407558 @default.
- W2073072010 cites W2067462759 @default.
- W2073072010 cites W2071393605 @default.
- W2073072010 cites W2076202013 @default.
- W2073072010 cites W2094534201 @default.
- W2073072010 cites W2095082570 @default.
- W2073072010 cites W2097430137 @default.
- W2073072010 cites W2099061568 @default.
- W2073072010 cites W2100265489 @default.
- W2073072010 cites W2100522677 @default.
- W2073072010 cites W2104594786 @default.
- W2073072010 cites W2106527113 @default.
- W2073072010 cites W2108322580 @default.
- W2073072010 cites W2120838187 @default.
- W2073072010 cites W2122261147 @default.
- W2073072010 cites W2123912039 @default.
- W2073072010 cites W2124801880 @default.
- W2073072010 cites W2125677667 @default.
- W2073072010 cites W2127249665 @default.
- W2073072010 cites W2130055485 @default.
- W2073072010 cites W2130183608 @default.
- W2073072010 cites W2131152565 @default.
- W2073072010 cites W2131166389 @default.
- W2073072010 cites W2133067224 @default.
- W2073072010 cites W2138401175 @default.
- W2073072010 cites W2139043349 @default.
- W2073072010 cites W2142622327 @default.
- W2073072010 cites W2143325288 @default.
- W2073072010 cites W2144364711 @default.
- W2073072010 cites W2148641266 @default.
- W2073072010 cites W2158040801 @default.
- W2073072010 cites W2158695705 @default.
- W2073072010 cites W2160084442 @default.
- W2073072010 cites W2165311878 @default.
- W2073072010 cites W2169898067 @default.
- W2073072010 cites W2259692038 @default.
- W2073072010 cites W2314625628 @default.
- W2073072010 cites W4211090384 @default.
- W2073072010 doi "https://doi.org/10.1371/journal.ppat.1002117" @default.
- W2073072010 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3131269" @default.
- W2073072010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21750675" @default.
- W2073072010 hasPublicationYear "2011" @default.
- W2073072010 type Work @default.
- W2073072010 sameAs 2073072010 @default.
- W2073072010 citedByCount "50" @default.
- W2073072010 countsByYear W20730720102012 @default.